Anti-Somatostatin Receptor 2/SSTR2 Antibody
Rabbit IgG polyclonal antibody for Somatostatin receptor type 2(SSTR2) detection. Tested with WB in Human;Mouse;Rat. Cited in 2 publication(s).
Anti-Somatostatin Receptor 2/SSTR2 Antibody Info At A Glance
|Reactivity:||Human, Mouse, Rat|
Your ideal low cost ELISA solution. EZ Set™ ELISA kit contains the necessary core reagents develop and run the ELISA, including ELISA-optimized matched antibody pairs, recombinant protein standards, and HRP conjugated Avidin-Biotin-Complex (ABC). One kit is sufficient for developing 5 plates (96 well format). EZ Set™ ELISAs are ideal for experienced ELISA users on a budget and great for exploratory work--a fast and easy way to identify the relevant protein targets of interest/relevance to your studies.
Boster also provides the most comprehensive technical support materials and most user friendly technical support service to guarantee that you can do the experiment smoothly and successfully.
|Product Name||Anti-Somatostatin Receptor 2/SSTR2 Antibody
See all Somatostatin R2/SSTR2 primary antibodies, ELISA kits and proteins
|Storage & Handling||At -20°C for one year. After reconstitution, at 4°C for one month. It can also be aliquotted and stored frozen at -20°C for a longer time.Avoid repeated freezing and thawing.|
|Description||Polyclonal antibody for Somatostatin R2/SSTR2 detection. Host: Rabbit.Size: 100μg/vial. Tested applications: WB. Reactive species: Human. Somatostatin R2/SSTR2 information: Molecular Weight: 41333 MW; Subcellular Localization: Cell membrane; Multi-pass membrane protein. Cytoplasm. Located mainly at the cell surface under basal conditions. Agonist stimulation results in internalization to the cytoplasm; Tissue Specificity: Expressed in both pancreatic alpha- and beta- cells (at protein level). Expressed at higher levels in the pancreas than other somatostatin receptors. Also expressed in the cerebrum and kidney and, in lesser amounts, in the jejunum, colon and liver. In the developing nervous system, expressed in the cortex where it is located in the preplate at early stages and is enriched in the outer part of the germinal zone at later stages. In the cerebellum, expressed in the deep part of the external granular layer at gestational week 19. This pattern persists until birth but disappears at adulthood.|
|Cite This Product||Anti-Somatostatin Receptor 2/SSTR2 Antibody (Boster Biological Technology, Pleasanton CA, USA, Catalog # PA1694)|
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|Anti-Somatostatin Receptor 2/SSTR2 Antibody may replace the following items: sc 25676|sc 365502|sc 11606.|
|Reactivity/Species||Human, Mouse, Rat|
*This antibody is predicted to react with the above species based on antigen sequence similarities. Our Boster Guarantee covers the use of this product with the above species.
*Our Boster Guarantee covers the use of this product in the above tested applications.
*Innovating Scientists reward: if you test this antibody on a species or application not listed above and share with us your results, we will provide you a full credit to purchase Boster products.
|Related Products||Boster recommends Enhanced Chemiluminescent Kit with anti-Rabbit IgG (EK1002) for Western blot.
*Blocking peptide can be purchased at $50. Contact us for more information.
**Boster also offers various secondary antibodies for Immunoflourescecne and IHC. Take advantage of the buy 1 primary antibody get 1 secondary antibody for free promotion all year round.
|Immunogen||A synthetic peptide corresponding to a sequence in the middle region of human Somatostatin Receptor 2(184-198aa RSNQWGRSSCTINWP), identical to the related rat and mouse sequences.|
|Cross Reactivity||No cross reactivity with other proteins|
Gene/Protein Basic Information For SSTR2 (Source: Uniprot.org, NCBI)
|NCBI Gene Id||6752|
|Species Of This Entry||Human|
|Protein Name||Somatostatin receptor type 2|
|Superfamily||G-protein coupled receptor 1 family|
|Alternative Names||Somatostatin R2/SSTR2|Smstr2; Somatostatin R2; somatostatin receptor 2; somatostatin receptor type 2; SomatostatinR2; SRIF-1; SS2R; SS-2-R; SS2-R; SST2; SSTR2|
|Post Tranlational Modifications||Phosphorylation; Cleavage; Demethylation; Biotinylation; Glycosylation; Methylation|
|Subcellular Localization||Cell membrane; Multi-pass membrane protein. Cytoplasm. Located mainly at the cell surface under basal conditions. Agonist stimulation results in internalization to the cytoplasm.|
|Gene Location||17q25.1, on Chromasome 17, gene sequence: NC_000017.11 (73165010..73176633)|
*if product is indicated to react with multiple species, protein info is based on the gene entry specified above in "species".
Ontology For SSTR2 (Source: Uniprot.org, NCBI)
|Protein Function||Receptor for somatostatin-14 and -28. This receptor is coupled via pertussis toxin sensitive G proteins to inhibition of adenylyl cyclase. In addition it stimulates phosphotyrosine phosphatase and PLC via pertussis toxin insensitive as well as sensitive G proteins. Inhibits calcium entry by suppressing voltage-dependent calcium channels. Acts as the functionally dominant somatostatin receptor in pancreatic alpha- and beta-cells where it mediates the inhibitory effect of somatostatin-14 on hormone secretion. Inhibits cell growth through enhancement of MAPK1 and MAPK2 phosphorylation and subsequent up-regulation of CDKN1B. Stimulates neuronal migration and axon outgrowth and may participate in neuron development and maturation during brain development. Mediates negative regulation of insulin receptor signaling through PTPN6. Inactivates SSTR3 receptor function following heterodimerization.|
|Tissue Specificity||Expressed in both pancreatic alpha- and beta- cells (at protein level). Expressed at higher levels in the pancreas than other somatostatin receptors. Also expressed in the cerebrum and kidney and, in lesser amounts, in the jejunum, colon and liver. In the developing nervous system, expressed in the cortex where it is located in the preplate at early stages and is enriched in the outer part of the germinal zone at later stages. In the cerebellum, expressed in the deep part of the external granular layer at gestational week 19. This pattern persists until birth but disappears at adulthood.|
|Interacting Proteins||PIK3R1; SSTR3|
|Research Areas||Alzheimers Research; Cancer; GPCR; Neuronal Cell Markers; Neuroscience; Neurotransmission|
|Related Diseases||Neoplasms; Pituitary Diseases; Malignant Neoplasms; Adenoma; Carcinoma; Pituitary Neoplasms; Pancreatic Neoplasm; Pituitary Adenoma; Neuroendocrine Tumors; Pertussis; Acromegaly; Neoplasm Metastasis; Malignant Paraganglionic Neoplasm; Carcinoid Tumor; Growth Hormone-secreting Pituitary Adenoma; Mammary Neoplasms; Prolactinoma; Nervousness; Malignant Neoplasm Of Breast|
|Related Pathways||Secretion; Cell Proliferation; Localization; Hormone Secretion; Cell Growth; Acid Secretion; Insulin Secretion; Gastric Acid Secretion; Angiogenesis; Cell Cycle; Growth Hormone Secretion; Glucagon Secretion; Cell Cycle Arrest; Reverse Transcription; Regulation Of Growth; Transport; Endocytosis; Cellular Localization; Excretion; Regulation Of Gastric Acid Secretion|
|Background||SSTR2(Somatostatin receptor type 2) is a protein that in humans is encoded by the SSTR2 gene. Somatostatin acts at many sites to inhibit the release of many hormones and other secretory proteins. The biologic effects of somatostatin are probably mediated by a family of G protein-coupled receptors that are expressed in a tissue-specific manner. SSTR2 is a member of the superfamily of receptors having seven transmembrane segments and is expressed in highest levels in cerebrum and kidney. Stable SSTR2 transfection of human pancreatic cells, which do not endogenously express SSTR2, inhibits cell proliferation, tumorigenicity, and metastasis. These effects occur as a consequence of an autocrine SSTR2-dependent loop, whereby SSTR2 induces expression of its own ligand, somatostatin.SSTR2 mRNA was variably expressed in all neuroblastoma tumors with a relevant reduction in the more advanced stage.|
|Scientific References||PMID: 1346068 by Yamada Y., et al. Cloning and functional characterization of a family of human and mouse somatostatin receptors expressed in brain, gastrointestinal tract, and kidney.|
PMID: 10619399 by Petersenn S., et al. Genomic structure and transcriptional regulation of the human somatostatin receptor type 2.
Our Boster Quality Guarantee for Anti-Somatostatin Receptor 2/SSTR2 Antibody covers its use in the following applications.Western blot, 0.1-0.5μg/ml, Rat, Human, Mouse
*The recommended dilution ratios/concentrations are for reference only and optimal dilutions/concentrations should be determined by the end user.
All lanes: Anti SSTR2 (PA1694) at 0.5ug/ml
WB: Rat Lung Tissue Lysate at 50ug
Predicted bind size: 41KD
Observed bind size: 55KD
Boster provides comprehensive technical information for WB, IHC/IF/ICC, Flow Cytometry sample preparation protocols, assay protocols, troubleshooting tips and assay optimization tips.
- Western Blottting Resource Center
- Immunohistochemistry Resource Center
- Flow Cytometry Technical Resource Center
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Total number of citations: 2
|Guo Rs, Shi Pd, Zhou J, Chen Yy. Asian Pac J Cancer Prev. 2013;14(7):4071-5. Somatostatin Receptors 3, 4 And 5 Play Important Roles In Gallbladder Cancer.||PubMed ID 23991955|
|Li M, Wang S, Wang S, Zhang L, Wu D, Yang R, Ji A, Li Y, Wang J. Exp Ther Med. 2017 Aug;14(2):1732-1738. doi: 10.3892/etm.2017.4651. Epub 2017 Jun 22. Occludin downregulation in high glucose is regulated by SSTR2 via the VEGF/NRP1/Akt signaling pa...||PubMed ID 28810643|
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