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Product Info Summary
| SKU: | A05084-1 |
|---|---|
| Size: | 0.1 mg |
| Reactive Species: | Human |
| Host: | Rabbit |
| Application: | ELISA, IHC-P |
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Product info
Product Name
Anti-TAB3 Antibody
SKU/Catalog Number
A05084-1
Size
0.1 mg
Form
Liquid
Description
Boster Bio Anti-TAB3 Antibody (Catalog # A05084-1). Tested in ELISA, IHC-P applications. This antibody reacts with Human.
Storage & Handling
TAB3 antibody can be stored at 4°C for three months and -20°C, stable for up to one year. Avoid repeated freeze-thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Cite This Product
Anti-TAB3 Antibody (Boster Biological Technology, Pleasanton CA, USA, Catalog # A05084-1)
Host
Rabbit
Contents
TAB3 Antibody is supplied in PBS containing 0.02% sodium azide.
Clonality
Polyclonal
Isotype
IgG
Immunogen
TAB3 antibody was raised against a 13 amino acid synthetic peptide near the amino terminus of human TAB3. The immunogen is located within amino acids 40 - 90 of TAB3.
Cross-reactivity
TAB3 antibody is human specific. TAB3 antibody is predicted not to cross-react with other TAB proteins.
Reactive Species
A05084-1 is reactive to TAB3 in Human
Observed Molecular Weight
68 kDa
Calculated molecular weight
78.7 kDa
Background of TAB3
TAB3 functions in the NF-kappaB signal transduction pathway. It and the similar and functionally redundant protein TAB2, form a ternary complex with the protein kinase TAK1 and either TRAF2 or TRAF6 in response to stimulation with the pro-inflammatory cytokines TNF or IL-1. Subsequent TAK1 kinase activity triggers a signaling cascade leading to activation of the NF-kappaB transcription factor. Recent experiments have shown that TAB2 and the related protein TAB3 constitutitvely interact with the autophagy mediator Beclin-1; upon induction of autophagy, these proteins dissociate from Beclin-1 and bind TAK1. Overexpression of TAB2 and TAB3 inhibit autophagy, while their depletion triggers it, suggesting that TAB2 and TAB3 act as a control point for autophagy.
Antibody Validation
Boster validates all antibodies on WB, IHC, ICC, Immunofluorescence, and ELISA with known positive control and negative samples to ensure specificity and high affinity, including thorough antibody incubations.
Application & Images
Applications
A05084-1 is guaranteed for ELISA, IHC-P Boster Guarantee
Assay Dilutions Recommendation
The recommendations below provide a starting point for assay optimization. The actual working concentration varies and should be decided by the user.
TAB3 antibody can be used for detection of TAB3 by immunohistochemistry at 5 μg/mL.
Antibody validated: Immunohistochemistry in human samples. All other applications and species not yet tested. Optimal dilutions for each application should be determined by the researcher.
Validation Images & Assay Conditions
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Immunohistochemistry of TAB3 in human kidney tissue with TAB3 antibody at 5 μg/mL.
Specific Publications For Anti-TAB3 Antibody (A05084-1)
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