Anti-TACE ADAM17 Antibody

TACE/ADAM17 antibody

Boster Bio Anti-TACE ADAM17 Antibody (Catalog # A00604-1). Tested in ELISA, WB, ICC, IF applications. This antibody reacts with Human, Rat.

Product Info Summary

SKU: A00604-1
Size: 0.1 mg
Reactive Species: Human, Rat
Host: Rabbit
Application: ELISA, IF, ICC, WB

Product Name

Anti-TACE ADAM17 Antibody

View all TACE/ADAM17 Antibodies

SKU/Catalog Number

A00604-1

Size

0.1 mg

Form

Liquid

Description

Boster Bio Anti-TACE ADAM17 Antibody (Catalog # A00604-1). Tested in ELISA, WB, ICC, IF applications. This antibody reacts with Human, Rat.

Storage & Handling

TACE antibody can be stored at 4°C for three months and -20°C, stable for up to one year. Avoid repeated freeze-thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Cite This Product

Anti-TACE ADAM17 Antibody (Boster Biological Technology, Pleasanton CA, USA, Catalog # A00604-1)

Host

Rabbit

Contents

TACE Antibody is supplied in PBS containing 0.02% sodium azide.

Clonality

Polyclonal

Isotype

IgG

Immunogen

Anti-TACE antibody was raised against a peptide corresponding to 17 amino acids near the carboxy terminus of human TACE. The immunogen is located within the last 50 amino acids of TACE.

*Blocking peptide can be purchased. Costs vary based on immunogen length. Contact us for pricing.

Cross-reactivity

80 to 130 kDa bands can be detected, which may represent mature protein, precursor, and glycosylated TACE.

Reactive Species

A00604-1 is reactive to ADAM17 in Human, Rat

Applications

A00604-1 is guaranteed for ELISA, IF, ICC, WB Boster Guarantee

Observed Molecular Weight

Calculated molecular weight

93.021kDa

Background of TACE/ADAM17

Tumor-necrosis factor-alpha is a proinflammatory cytokine and contributes to a variety of inflammatory disease responses and programmed cell death. TNF-α is synthesized as a 26K type II membrane-bound precursor that is cleaved by a convertase to generate secreted 17K mature TNF-α. TNF-α converting enzyme (TACE) protein was recently purified and the human and mouse TACE cDNAs were cloned by several groups separately. TACE is a membrane-bound metalloprotease-disintegrin in the family of mammalian ADAM (for a disintegrin and metalloprotease). TACE also processes other cell surface proteins, including TNF receptor, TGFalpha, the L-selectin adhesion molecule, and alpha-cleavage of amyloid protein precursor (APP). TACE mRNA is expressed in a variety of human and murine tissues. TACE was selected as one of the few targets in cytokine activation by the Eighth International Conference of the Inflammation Research Association.

Antibody Validation

Boster validates all antibodies on WB, IHC, ICC, Immunofluorescence, and ELISA with known positive control and negative samples to ensure specificity and high affinity, including thorough antibody incubations.

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Assay Dilutions Recommendation

The recommendations below provide a starting point for assay optimization. The actual working concentration varies and should be decided by the user.

WB: 0.25-2 μg/mL; ICC: 10 μg/mL; IF: 10 μg/mL.
Antibody validated: Western Blot in human and rat samples; Immunocytochemistry in human samples; and Immunofluorescence in human and rat samples. All other applications and species not yet tested. Optimal dilutions for each application should be determined by the researcher.

Validation Images & Assay Conditions

Gene/Protein Information For ADAM17 (Source: Uniprot.org, NCBI)

Gene Name

ADAM17

Full Name

Disintegrin and metalloproteinase domain-containing protein 17

Weight

93.021kDa

Alternative Names

ADAM 17; ADAM metallopeptidase domain 17; ADAM metallopeptidase domain 18; ADAM17; ADAM18; CD156b antigen; CD156b; CSVP; disintegrin and metalloproteinase domain-containing protein 17; EC 3.4.24.86; MGC71942; Snake venom-like protease; TACE; TACEcSVP; TNF-alpha convertase; TNF-alpha converting enzyme; TNF-alpha-converting enzyme; tumor necrosis factor, alpha, converting enzyme ADAM17 ADAM18, CD156B, CSVP, NISBD, NISBD1, TACE ADAM metallopeptidase domain 17 disintegrin and metalloproteinase domain-containing protein 17|ADAM metallopeptidase domain 18|TNF-alpha convertase|TNF-alpha convertase enzyme|TNF-alpha converting enzyme|a disintegrin and metalloproteinase 17|cartilage snake venom-like protease|snake venom-like protease|tumor necrosis factor, alpha, converting enzyme

*If product is indicated to react with multiple species, protein info is based on the gene entry specified above in "Species".

For more info on ADAM17, check out the ADAM17 Infographic

ADAM17 infographic

We have 30,000+ of these available, one for each gene! Check them out.

In this infographic, you will see the following information for ADAM17: database IDs, superfamily, protein function, synonyms, molecular weight, chromosomal locations, tissues of expression, subcellular locations, post-translational modifications, and related diseases, research areas & pathways. If you want to see more information included, or would like to contribute to it and be acknowledged, please contact [email protected].

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Size

Total: $449

SKU:A00604-1

Backordered.

Lead time for this item is typically 4-7 days

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A00604-1
Buy one primary antibody get one 0.5ml HRP or Biotin secondary antibody for free.
*Sample sizes are prepared on demand and will take extra lead time. (cannot be conjugated)
$449.00

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