Anti-TCIRG1 Antibody

Product Name

Anti-TCIRG1 Antibody

View all TCIRG1 Antibodies

SKU/Catalog Number

A05045

Size

0.1 mg

Form

Liquid

Description

Boster Bio Anti-TCIRG1 Antibody (Catalog # A05045). Tested in ELISA, WB applications. This antibody reacts with Human, Mouse, Rat.

Storage & Handling

TCIRG1 antibody can be stored at 4°C for three months and -20°C, stable for up to one year. Avoid repeated freeze-thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Cite This Product

Anti-TCIRG1 Antibody (Boster Biological Technology, Pleasanton CA, USA, Catalog # A05045)

Host

Rabbit

Contents

TCIRG1 Antibody is supplied in PBS containing 0.02% sodium azide.

Clonality

Polyclonal

Clone Number

Clone: SK7

Isotype

IgG

Immunogen

TCIRG1 antibody was raised against a 19 amino acid synthetic peptide near the amino terminus of human TCIRG1. The immunogen is located within amino acids 70 - 120 of TCIRG1.

*Blocking peptide can be purchased. Costs vary based on immunogen length. Contact us for pricing.

Cross-reactivity

At least two alternatively spliced isoforms are known to exist; this antibody will only detect the larger isoform.

Reactive Species

A05045 is reactive to TCIRG1 in Human, Mouse, Rat

Applications

A05045 is guaranteed for ELISA, WB Boster Guarantee

Observed Molecular Weight

68 kDa

Calculated molecular weight

92.968kDa

Background of TCIRG1

The T-cell immune regulator 1 (TCIRG1) is the a3 subunit of the vacuolar-type proton transporting ATPase (V-ATPase), a proton pump in late endosomes and lysosomes that functions in the luminal acidification of these organelles. Genetic defects in the gene encoding this protein a responsible for a severe form of autosomal recessive osteopetrosis, a condition that leads to increased bone density, decreased bone strength, and inflammation in bone tissues. TCIRG1 is also required for the normal secretion of insulin and the bacteria-killing function of macrophages.

Antibody Validation

Boster validates all antibodies on WB, IHC, ICC, Immunofluorescence, and ELISA with known positive control and negative samples to ensure specificity and high affinity, including thorough antibody incubations.

View more details

Innovating Scientists Reward

If you are the first to review this product, or if you have results for a special sample, species or application this product is not validated in, share your results with us and receive product credits you can use towards any Boster products! Applicable to all scientists worldwide.

Submit A Review

Assay Dilutions Recommendation

The recommendations below provide a starting point for assay optimization. The actual working concentration varies and should be decided by the user.

TCIRG1 antibody can be used for detection of TCIRG1 by Western blot at 0.5 μg/mL.
Antibody validated: Western Blot in mouse samples. All other applications and species not yet tested. Optimal dilutions for each application should be determined by the researcher.

Validation Images & Assay Conditions

Click image to see more details

Western blot analysis of TCIRG1 in EL4 cell lysate with TCIRG1 antibody at 0.5 μg/ml in (A) the absence and (B) the presence of blocking peptide.

Gene/Protein Information For TCIRG1 (Source: Uniprot.org, NCBI)

Alternative Names

a3; Atp6i; ATP6N1C; ATP6N1Cspecific 116-kDa vacuolar proton pump subunit; ATP6V0A3T-cell immune response cDNA 7; OC-116 kDa; OC116; OC-116; OC-116kDa; OC116Vph1; OPTB1; Osteoclastic proton pump 116 kDa subunit; Stv1; T-cell immune regulator 1; T-cell immune response cDNA7 protein; T-cell, immune regulator 1; T-cell, immune regulator 1, ATPase, H+ transporting, lysosomal V0 protein a; T-cell, immune regulator 1, ATPase, H+ transporting, lysosomal V0 protein A3; T-cell, immune regulator 1, ATPase, H+ transporting, lysosomal V0 protein aisoform 3; T-cell, immune regulator 1, ATPase, H+ transporti TCIRG1 ATP6N1C, ATP6V0A3, Atp6i, OC-116kDa, OC116, OPTB1, Stv1, TIRC7, Vph1, a3 T cell immune regulator 1, ATPase H+ transporting V0 subunit a3 V-type proton ATPase 116 kDa subunit a3|ATPase, H+ transporting, 116kD|T-cell immune response cDNA 7|T-cell, immune regulator 1, ATPase, H+ transporting, lysosomal V0 protein a|T-cell, immune regulator 1, ATPase, H+ transporting, lysosomal V0 subunit A3|V-ATPase 116 kDa subunit a3|V-ATPase 116-kDa|V-type proton ATPase 116 kDa subunit a|osteoclastic proton pump 116 kDa subunit|specific 116-kDa vacuolar proton pump subunit|vacuolar proton translocating ATPase 116 kDa subunit A

For more info on TCIRG1, check out the TCIRG1 Infographic

We have 30,000+ of these available, one for each gene! Check them out.

In this infographic, you will see the following information for TCIRG1: database IDs, superfamily, protein function, synonyms, molecular weight, chromosomal locations, tissues of expression, subcellular locations, post-translational modifications, and related diseases, research areas & pathways. If you want to see more information included, or would like to contribute to it and be acknowledged, please contact [email protected].

Take me to the TCIRG1 Infographic

Here are featured tools and databases that you might find useful.

• Boster's Pathways Library
• Protein Databases
• Bioscience Research Protocol Resources
• Data Processing & Analysis Software
• Photo Editing Software
• Scientific Literature Resources
• Research Paper Management Tools
• Molecular Biology Software
• Primer Design Tools
• Bioinformatics Tools
• Phylogenetic Tree Analysis