Anti-THOC5/Fmip Antibody

Product Name

Anti-THOC5/Fmip Antibody

View all THOC5 Antibodies

SKU/Catalog Number

A04619

Size

100 µl

Form

Liquid

Description

Boster Bio Anti-THOC5/Fmip Antibody (Catalog # A04619). Tested in WB, IHC applications. This antibody reacts with Human.

Storage & Handling

Store at -20°C for one year. For short term storage and frequent use, store at 4°C for up to one month. Avoid repeated freeze-thaw cycles.

Cite This Product

Anti-THOC5/Fmip Antibody (Boster Biological Technology, Pleasanton CA, USA, Catalog # A04619)

Host

Rabbit

Contents

Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

Clonality

Polyclonal

Isotype

IgG

Immunogen

Synthesized peptide derived from internal of human THOC5.

*Blocking peptide can be purchased. Costs vary based on immunogen length. Contact us for pricing.

Reactive Species

A04619 is reactive to THOC5 in Human

Applications

A04619 is guaranteed for IHC, WB Boster Guarantee

Observed Molecular Weight

Calculated molecular weight

78.508kDa

Background of THOC5

Acts as component of the THO subcomplex of the TREX complex which is thought to couple mRNA transcription, processing and nuclear export, and which specifically associates with spliced mRNA and not with unspliced pre-mRNA. TREX is recruited to spliced mRNAs by a transcription-independent mechanism, binds to mRNA upstream of the exon-junction complex (EJC) and is recruited in a splicing- and cap-dependent manner to a region near the 5' end of the mRNA where it functions in mRNA export to the cytoplasm via the TAP/NFX1 pathway. The TREX complex is essential for the export of Kaposi's sarcoma-associated herpesvirus (KSHV) intronless mRNAs and infectious virus production. THOC5 in conjunction with ALYREF/THOC4 functions in NXF1-NXT1 mediated nuclear export of HSP70 mRNA; both proteins enhance the RNA binding activity of NXF1 and are required for NXF1 localization to the nuclear rim. Involved in transcription elongation and genome stability. Involved in alternative polyadenylation site choice by recruiting CPSF6 to 5' region of target genes; probaly mediates association of the TREX and CFIm complexes. Regulates the expression of myeloid transcription factors CEBPA, CEBPB and GAB2 by enhancing the levels of phosphatidylinositol 3,4,5-trisphosphate. May be involved in the differentiation of granulocytes and adipocytes. Essential for hematopoietic primitive cell survival and plays an integral role in monocytic development.

Xie Y.G., Hum. Mol. Genet. 2:1361-1368(1993).
Nagase T., DNA Res. 6:63-70(1999).
Collins J.E., Genome Biol. 5:RESEARCH84.1-RESEARCH84.11(2004)

Antibody Validation

Boster validates all antibodies on WB, IHC, ICC, Immunofluorescence, and ELISA with known positive control and negative samples to ensure specificity and high affinity, including thorough antibody incubations.

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Assay Dilutions Recommendation

The recommendations below provide a starting point for assay optimization. The actual working concentration varies and should be decided by the user.

Western blotting: 1:500~1:3000
Immunohistochemistry: 1:50~1:100

Validation Images & Assay Conditions

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Western blot analysis of extracts from JK cells and HepG2 cells, using THOC5 antiobdy A04619.

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Immunohistochemistry analysis of paraffin-embedded human breast carcinoma tissue using THOC5 antibody A04619.

Gene/Protein Information For THOC5 (Source: Uniprot.org, NCBI)

Alternative Names

C22orf19; chromosome 22 open reading frame 19; Fmip; Fms-interacting protein; fSAP79hTREX90; Functional spliceosome-associated protein 79; KIAA0983; NF2/meningioma region protein pK1.3; PK1.3; Placental protein 39.2; PP39.2; THO complex 5; THO complex subunit 5 homolog THOC5 C22orf19, Fmip, PK1.3, fSAP79 THO complex 5 THO complex subunit 5 homolog|Fms-interacting protein|NF2/meningioma region protein pK1.3|PP39.2|functional spliceosome-associated protein 79|hTREX90|placental protein 39.2

For more info on THOC5, check out the THOC5 Infographic

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In this infographic, you will see the following information for THOC5: database IDs, superfamily, protein function, synonyms, molecular weight, chromosomal locations, tissues of expression, subcellular locations, post-translational modifications, and related diseases, research areas & pathways. If you want to see more information included, or would like to contribute to it and be acknowledged, please contact [email protected].

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