Anti-Thyroid hormone receptor alpha THRA Antibody

Product Name

Anti-Thyroid hormone receptor alpha THRA Antibody

View all THRA Antibodies

SKU/Catalog Number

A01775

Size

100ug

Form

Liquid (sterile filtered)

Description

Boster Bio Anti-Thyroid hormone receptor alpha THRA Antibody (Catalog # A01775). Tested in ELISA, WB applications. This antibody reacts with Human.

Storage & Handling

Store vial at -20°C prior to opening. Aliquot contents and freeze at -20°C or below for extended storage. Avoid cycles of freezing and thawing. Centrifuge product if not completely clear after standing at room temperature. This product is stable for several weeks at 4°C as an undiluted liquid. Dilute only prior to immediate use. Expiration date is one (1) year from date of opening. (Ship on dry ice.)

Cite This Product

Anti-Thyroid hormone receptor alpha THRA Antibody (Boster Biological Technology, Pleasanton CA, USA, Catalog # A01775)

Host

Rabbit

Contents

0.02 M Potassium Phosphate, 0.15 M Sodium Chloride, pH 7.2, 0.01% (w/v) Sodium Azide

Clonality

Polyclonal

Isotype

IgG

Immunogen

This affinity purified antibody was prepared from whole rabbit serum produced by repeated immunizations with a synthetic peptide corresponding to a region near the amino terminus of human THRA isoform 1 protein.

Reactive Species

A01775 is reactive to THRA in Human

Observed Molecular Weight

42 kDa

Background of THRA

This antibody is suitable for Cancer, Immunology and Nuclear Signaling research. Thyroid hormone receptor alpha is a nuclear hormone receptor with high affinity for the hormone triiodo-thyronine. THRA is one of the several receptors for thyroid hormone, and has been shown to mediate the biological activities of thyroid hormone. Knockout studies in mice suggest that the different receptors, while having a certain extent of redundancy, may mediate different functions of thyroid hormone. THRA interacts with NCOA3 and NCOA6 co-activators, leading to a strong increase in transcription of target genes. THRA is localized within the nucleus and has been found to exist as 4 isoforms originating from alternative splicing variants. This antibody recognizes THRA isoform 1. Isoform 1 has a distinct C-terminus compared to isoform 2.

Antibody Validation

Boster validates all antibodies on WB, IHC, ICC, Immunofluorescence, and ELISA with known positive control and negative samples to ensure specificity and high affinity, including thorough antibody incubations.

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Applications

A01775 is guaranteed for ELISA, IP, IF, IHC, WB Boster Guarantee

Assay Dilutions Recommendation

The recommendations below provide a starting point for assay optimization. The actual working concentration varies and should be decided by the user.

ELISA: 1:300,000
IHC: 1:200
IF Microscopy: 1:200
IP: 1:100
WB: 1:500 - 1:2,000
This affinity purified antibody has been tested for use in ELISA and western blotting.

Validation Images & Assay Conditions

See full target information THRA

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