ABCC8 Antibodies

AND ABCC8 ELISA kits, ABCC8 Proteins

Many biological assays use antibodies to detect ABCC8, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with ABCC8 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop ABCC8 antibodies...

We validate the specificity of these antibodies to ABCC8 by testing them on tissues known to express ABCC8 positively and negatively. Browse below to find the ABCC8 antibody that suites your experiment. We have 1 of these antibodies and many publications and validation images.

If you cannot find antibodies that fit your needs, contact us for making custom antibodies. We have a full suite of custom antibody services covering from research to diagnostic and therapeutic applications.

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ABCC8 Infographic by Boster Bio

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Anti-SUR1/ABCC8 Antibody Picoband®

1 Q&As

Western blot analysis of SUR1 using anti-SUR1 antibody (A00895-1)

Flow Cytometry analysis of A431 cells using anti-ABCC8 antibody (A00895-1)

Human, Mouse, Rat

Flow Cytometry, IHC, ICC, WB

$370
Cat # A00895-1
100 μg/vial

ABCC8 Overview

Facts about ATP-binding cassette sub-family C member 8.

ABCC8 3D structure. Source: alphafold

ATP-binding cassette sub-family C member 8 (ABCC8)

Subunit of the beta-cell ATP-sensitive potassium channel (KATP). Regulator of ATP-sensitive K(+) channels and insulin release.

Gene Information

Human
Gene Name:	ABCC8
Uniprot:	Q09428
Entrez:	6833

Family

Belongs to:

ABC transporter superfamily

Alternative Names

ABC36; ATP-binding cassette, sub-family C (CFTR/MRP), member 8; HHF1Sulfonylurea receptor 1; HI; PHHIHRINS; sulfonylurea receptor (hyperinsulinemia); SUR1MRP8; SURATP-binding cassette transporter sub-family C member 8; TNDM2ATP-binding cassette sub-family C member 8

Molecular Weight

Mass (kDA):
176.992 kDA

Genomic Context


Human

Location:	11p15.1
Sequence:	11; NC_000011.10 (17392498..17476849, complement)

Subcellular Localizations

Cell membrane; Multi-pass membrane protein.

Diseases

Diabetes Mellitus
Hyperinsulinism
Hypoglycemia
Persistent Hyperinsulinemia Hypoglycemia Of Infancy
Diabetes Mellitus, Non-insulin-dependent
Diabetes Mellitus, Insulin-dependent
Hyperglycemia
Developmental Delay (disorder)
Impaired Glucose Tolerance
Epilepsy
Hypoglycemia Of Infancy
Obesity

Brain Injuries
Nesidioblastosis
Insulin Resistance
Insulin Sensitivity
Hyperplasia
Congenital Absence

Interacting Proteins

KCNJ11

Pathways

Secretion
Insulin Secretion
Transport
Glucose Homeostasis
Pathogenesis
Regulation Of Insulin Secretion
Methylation
Localization
Drug Resistance
Fatty Acid Oxidation
Inflammatory Response
Translation
Dna Methylation

Glycosylation
Endocytosis
Cell Death
Clathrin-mediated Endocytosis
Dna Hypomethylation
Protein Secretion
Drug Transport

PTMs

Methylation
Glycosylation
Demethylation

Carboxylation
Phosphorothioation
Oxidation

Research Areas

ABC Transporters
Lipid and Metabolism
Neuroscience

For details, visit:
bosterbio.com/bosterbio-gene-info-cards/ABCC8

References

PMID: 21671119 by Schmid D., et al. An abundant, truncated human sulfonylurea receptor 1 splice variant has prodiabetic properties and impairs sulfonylurea action.

PMID: 7716548 by Thomas P.M., et al. Mutations in the sulfonylurea receptor gene in familial persistent hyperinsulinemic hypoglycemia of infancy.