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- Table of Contents
ABCG8 Antibodies
AND ABCG8 ELISA kits, ABCG8 Proteins
Many biological assays use antibodies to detect ABCG8, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with ABCG8 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop ABCG8 antibodies...
Designing a Western blot for ABCG8? The guide has the expected band size, antibodies backed by real blot images, the controls to run alongside, and protocols taken from published papers.
Open the ABCG8 Western Blot GuideABCG8 Infographic by Boster Bio
All ABCG8 Products
Product
Figures
Specificity
Applications
Price
Anti-ABCG8 Antibody Picoband®
2 Citations
Human, Mouse, Rat
IF, ICC, WB
$370
Cat # A01482-1
100 μg/vial
Cat # A01482-1
100 μg/vial
Anti-ABCG8 Antibody Picoband®
1 Citations
Human, Mouse, Rat
ELISA, Flow Cytometry, IF, ICC, WB
$370
Cat # A01482-2
100 μg/vial
Cat # A01482-2
100 μg/vial
ABCG8 Overview
Facts about ATP-binding cassette sub-family G member 8.
ATP-binding cassette sub-family G member 8 (ABCG8)
ABCG5 and ABCG8 form an obligate heterodimer that mediates Mg(2+)- and ATP-dependent sterol transport throughout the cell membrane. Plays an important role in the selective transport of the dietary cholesterol in and out of the enterocytes and in the selective sterol excretion from the liver into bile (PubMed:11099417, PubMed:11452359, PubMed:27144356, PubMed:15054092).
Required for normal sterol homeostasis (PubMed:11099417, PubMed:11452359, PubMed:15054092). The heterodimer with ABCG5 has ATPase activity (PubMed:16893193, PubMed:20210363, PubMed:27144356).
Gene Information
| Human | |
|---|---|
| Gene Name: | ABCG8 |
| Uniprot: | Q9H221 |
| Entrez: | 64241 |
Family
| Belongs to: |
|---|
| ABC transporter superfamily |
Alternative Names
ATP-binding cassette sub-family G member 8; ATP-binding cassette, sub-family G (WHITE), member 8 (sterolin 2); ATP-binding cassette, sub-family G (WHITE), member 8; GBD4ATP-binding cassette, subfamily G, member 8; MGC142217; sterolin 2; sterolin-2; STSL
Molecular Weight
Mass (kDA):
75.679 kDA
Genomic Context
| Human | |
|---|---|
| Location: | 2p21 |
| Sequence: | 2; NC_000002.12 (43831942..43882988) |
Tissue Specificity
Predominantly expressed in the liver (PubMed:11099417, PubMed:11452359). Low expression levels in the small intestine and colon (PubMed:11099417). Very low levels in other tissues, including brain, heart and spleen (PubMed:11452359).
Subcellular Localizations
Cell membrane; Multi-pass membrane protein. Apical cell membrane; Multi-pass membrane protein.
Diseases
- Sitosterolemia
- Hypercholesterolemia
- Atherosclerosis
- Cholecystolithiasis
- Cardiovascular Diseases
- Hyperlipidemia
- Insulin Resistance
- Malignant Neoplasms
- Cholelithiasis
- Coronary Artery Disease
- Inflammation
- Coronary Heart Disease
Interacting Proteins
- ABCG5
Pathways
- Transport
- Secretion
- Excretion
- Cholesterol Transport
- Intestinal Cholesterol Absorption
- Cholesterol Homeostasis
- Cholesterol Efflux
- Reverse Cholesterol Transport
- Intestinal Absorption
- Gallstone Formation
- Sterol Transport
- Localization
- Lipid Homeostasis
PTMs
- Oxidation
- Phosphorylation
- Glycosylation
- Methylation
- Carboxylation
Research Areas
- ABC Transporters
- Cancer
- Cholesterol Metabolism
- Lipid and Metabolism
- Signal Transduction
For details, visit:
bosterbio.com/bosterbio-gene-info-cards/ABCG8
bosterbio.com/bosterbio-gene-info-cards/ABCG8
References
PMID: 11099417 by Berge K.E., et al. Accumulation of dietary cholesterol in sitosterolemia caused by mutations in adjacent ABC transporters.
PMID: 11452359 by Lu K., et al. Two genes that map to the STSL locus cause sitosterolemia: genomic structure and spectrum of mutations involving sterolin-1 and sterolin- 2, encoded by ABCG5 and ABCG8, respectively.
1 Publications of Boster ABCG8 Antibodies & ELISA Kits
- PubMed ID: 33317360, Huang J,Wang Q,Chen M,Bi Y,Shi H,Zhou K. Effects of psoralen on hepatic bile aci...
*More publications can be found for each product on its corresponding product page