ACAD8 Antibodies

AND ACAD8 ELISA kits, ACAD8 Proteins

Many biological assays use antibodies to detect ACAD8, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with ACAD8 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop ACAD8 antibodies...

We validate the specificity of these antibodies to ACAD8 by testing them on tissues known to express ACAD8 positively and negatively. Browse below to find the ACAD8 antibody that suites your experiment. We have 2 of these antibodies and many publications and validation images.

If you cannot find antibodies that fit your needs, contact us for making custom antibodies. We have a full suite of custom antibody services covering from research to diagnostic and therapeutic applications.

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ACAD8 Infographic by Boster Bio

All ACAD8 Products

Product

Figures

Specificity

Applications

Price

ACAD8 (NM_014384) Human Recombinant Protein

$1249
Cat # PROTQ9UKU7
20 µg

ACAD8 (NM_014384) Human Over-expression Lysate

Human

$628
Cat # LS027034
100 µg

ACAD8 Overview

Facts about Isobutyryl-CoA dehydrogenase, mitochondrial.

ACAD8 3D structure. Source: alphafold

Isobutyryl-CoA dehydrogenase, mitochondrial (ACAD8)

Has very high activity toward isobutyryl-CoA. Is an isobutyryl-CoA dehydrogenase that works in valine catabolism.

Plays a role in transcriptional coactivation inside the ARC complex. .

Gene Information

Human
Gene Name:	ACAD8
Uniprot:	Q9UKU7
Entrez:	27034

Family

Belongs to:

acyl-CoA dehydrogenase family

Alternative Names

ACAD-8; Activator-recruited cofactor 42 kDa component; Acyl-CoA dehydrogenase family member 8; acyl-CoA dehydrogenase family, member 8; acyl-Coenzyme A dehydrogenase family, member 8; ARC42; EC 1.3.99; EC 1.3.99.-; FLJ22590; IBD; isobutyryl-CoA dehydrogenase, mitochondrial

Molecular Weight

Mass (kDA):
45.07 kDA

Genomic Context


Human

Location:	11q25
Sequence:	11; NC_000011.10 (134253538..134265858)

Tissue Specificity

Detected at comparable levels in all tissues examined (heart, lung, brain, skeletal muscle, pancreas and placenta). Weakly expressed in liver and kidney.

Subcellular Localizations

Mitochondrion.

Diseases

Deficiency Of Isobutyryl-coa Dehydrogenase
Inborn Errors Of Metabolism
Cardiomyopathies
Multiple Acyl Coenzyme A Dehydrogenase Deficiency
Deficiency Of Butyryl-coa Dehydrogenase
Malnutrition
Dehydration
Malignant Neoplasms
Sudden Death
Long Chain Acyl-coa Dehydrogenase Deficiency
Cold Intolerance

Hypoglycemia
Fatty Liver
Glutaric Aciduria, Type 1
Anemia
Steatohepatitis
Steatosis

Pathways

Translation
Protein Folding

PTMs

Oxidation

Research Areas

Core ESC-Like Genes
Stem Cell Markers

For details, visit:
bosterbio.com/bosterbio-gene-info-cards/ACAD8

References

PMID: 10524212 by Telford E.A.R., et al. Isolation and characterisation of a cDNA encoding the precursor for a novel member of the acyl-CoA dehydrogenase gene family.

PMID: 10235267 by Naeaer A.M., et al. Composite co-activator ARC mediates chromatin-directed transcriptional activation.