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Component of the ASAP complexes which bind RNA in a sequence- independent manner and are suggested to be recruited to the EJC before or during the splicing process and to modulate specific excision of introns in particular transcription subsets; ACIN1 confers RNA-binding to the complicated. The ASAP complex can inhibit RNA processing during in vitro splicing reactions.
|Sequence:||14; NC_000014.9 (23058564..23095614, complement)|
Ubiquitous. The Ser-1180 phosphorylated form (by SRPK2) is highly expressed and phosphorylated in patients with myeloid hematologic malignancies.
Nucleus. Nucleus speckle. Nucleus, nucleoplasm. Phosphorylation on Ser-1180 by SRPK2 redistributes it from the nuclear speckles to the nucleoplasm.