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- Table of Contents
Facts about Disintegrin and metalloproteinase domain-containing protein 22.
Involved in regulation of cell adhesion and spreading and in inhibition of cell proliferation (By similarity). Neuronal receptor for LGI1.
Mouse | |
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Gene Name: | Adam22 |
Uniprot: | Q9R1V6 |
Entrez: | 11496 |
Belongs to: |
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No superfamily |
ADAM 22; ADAM metallopeptidase domain 22; ADAM22; MDC2; metalloproteinase-disintegrin ADAM22-3; metalloproteinase-like, disintegrin-like, and cysteine-rich protein 2; MGC149832
Mass (kDA):
99.715 kDA
Mouse | |
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Location: | 5 A1|5 3.39 cM |
Sequence: | 5; |
Detected in juxtaparanodal zones in the central nervous system and at nerve terminal plexuses of basket cells in the cerebellum (at protein level) (PubMed:20089912). Expressed at high levels in the brain. Strongly expressed in cerebellar granule cells and hippocampus. In spinal cord, expression is restricted to gray matter.
PMID: 10433968 by Sagane K., et al. Cloning and chromosomal mapping of mouse ADAM11, ADAM22 and ADAM23.
PMID: 15876356 by Sagane K., et al. Ataxia and peripheral nerve hypomyelination in ADAM22-deficient mice.