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- Table of Contents
Protein argonaute-1 Antibodies
AND AGO1 ELISA kits, Protein argonaute-1 Proteins
Many biological assays use antibodies to detect Protein argonaute-1, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with Protein argonaute-1 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop Protein argonaute-1 antibodies...
Designing a Western blot for Protein argonaute-1? The guide has the expected band size, antibodies backed by real blot images, the controls to run alongside, and protocols taken from published papers.
Open the AGO1 Western Blot GuideAGO1 Infographic by Boster Bio
All AGO1 Products
Product
Figures
Specificity
Applications
Price
Human, Mouse, Rat
ELISA, Flow Cytometry, WB
$370
Cat # A00826-3
100 μg/vial
Cat # A00826-3
100 μg/vial
Human, Mouse, Rat
IHC, WB
$523
Cat # M00826
100 µl
Cat # M00826
100 µl
AGO1 Overview
Facts about Protein argonaute-1.
Protein argonaute-1 (AGO1)
Required for RNA-mediated gene silencing (RNAi). Binds to short RNAs such as microRNAs (miRNAs) or short interfering RNAs (siRNAs), and represses the translation of mRNAs that are complementary to them.
Lacks endonuclease activity and does not appear to cleave target mRNAs. Also required for transcriptional gene silencing (TGS) of promoter regions that are complementary to bound brief antigene RNAs (agRNAs).
Gene Information
| Human | |
|---|---|
| Gene Name: | AGO1 |
| Uniprot: | Q9UL18 |
| Entrez: | 26523 |
Family
| Belongs to: |
|---|
| argonaute family |
Alternative Names
AGO1Q99; argonaute 1; argonaute1; DKFZp686M13167; eIF2C 1; eIF-2C 1; EIF2C; Eukaryotic translation initiation factor 2C 1; eukaryotic translation initiation factor 2C, 1; GERP95; Golgi Endoplasmic Reticulum protein 95 kDa; hAgo1; protein argonaute-1; Putative RNA-binding protein Q99
Molecular Weight
Mass (kDA):
97.214 kDA
Genomic Context
| Human | |
|---|---|
| Location: | 1p34.3 |
| Sequence: | 1; NC_000001.11 (35869808..35930532) |
Subcellular Localizations
Cytoplasm, P-body.
Diseases
- Malignant Neoplasms
- Neoplasms
- Immunologic Deficiency Syndromes
- Neuroblastoma
- Virus Diseases
- Neoplasm Metastasis
- Malignant Neoplasm Of Breast
- Mammary Neoplasms
- Inflammation
- Neurodegenerative Disorders
- Cell Invasion
- Hiv Infections
- Melanoma
Interacting Proteins
- AGO2
- DICER1
- HSP90AB1
- IPO8
- PPP5C
- PRNP
- TNRC6A
Pathways
- Gene Silencing
- Translation
- Rna Interference
- Mrna Cleavage
- Methylation
- Localization
- Dna Methylation
- Mrna Processing
- Cell Proliferation
- Posttranscriptional Gene Silencing
- Pathogenesis
- Viral Replication
- Heterochromatin Assembly
PTMs
- Cleavage
- Methylation
For details, visit:
bosterbio.com/bosterbio-gene-info-cards/AGO1
bosterbio.com/bosterbio-gene-info-cards/AGO1
References
PMID: 10534406 by Koesters R., et al. Human eukaryotic initiation factor EIF2C1 gene: cDNA sequence, genomic organization, localization to chromosomal bands 1p34-p35, and expression.
PMID: 15260970 by Meister G., et al. Human Argonaute2 mediates RNA cleavage targeted by miRNAs and siRNAs.