Type-1 angiotensin II receptor-associated protein (Agtrap)

Appears to be a negative regulator of type-1 angiotensin II receptor-mediated signaling by regulating receptor internalisation as well as mechanism of receptor desensitization like phosphorylation. Induces also a reduction in angiotensin II-stimulated transcriptional activity.

May play a role of negative regulator in cardiomyocyte hypertrophy induced by angiotensin II through an inhibition of p38 mitogen-activated protein kinase pathway. .