Delta-1-pyrroline-5-carboxylate dehydrogenase, mitochondrial (ALDH4A1)

Irreversible conversion of delta-1-pyrroline-5- carboxylate (P5C), derived from proline or ornithine, to glutamate. This is a essential step in the pathway interconnecting the urea and tricarboxylic acid cycles.

The preferred substrate is glutamic gamma-semialdehyde, other substrates include succinic, glutaric and adipic semialdehydes. .