Ankyrin repeat and LEM domain-containing protein 2 (ANKLE2)

Involved in mitotic nuclear envelope reassembly by promoting dephosphorylation of BAF/BANF1 during mitotic exit. Coordinates the control of BAF/BANF1 dephosphorylation by inhibiting VRK1 kinase and promoting dephosphorylation of BAF/BANF1 by protein phosphatase 2A (PP2A), thereby facilitating nuclear envelope assembly.

It is unclear whether it acts as a real PP2A regulatory subunit or if it is involved in recruitment of the PP2A complex. Involved in brain development (PubMed:25259927).