Ankyrin repeat domain-containing protein 17 (ANKRD17)

Could play pivotal roles in cell cycle and DNA regulation (PubMed:19150984). Involved in innate immune defense against viruse by positively regulating the viral dsRNA receptors DDX58 and IFIH1 signaling pathways (PubMed:22328336).

Involves in NOD2- and NOD1-mediated answers to bacteria indicating a role in innate antibacterial immune pathways also (PubMed:23711367). Target of enterovirus 71 which is the major etiological agent of HFMD (hand, foot and mouth disease) (PubMed:17276651).