AP-2 complex subunit beta Antibodies

AP-2 complex subunit beta (AP2B1)

Component of the adaptor protein complex 2 (AP-2). Adaptor protein complexes function in protein transport via transport vesicles in different membrane traffic pathways.

Adaptor protein complexes are vesicle coat components and seem to be involved in cargo selection and vesicle formation. AP-2 is involved in clathrin-dependent endocytosis in which cargo proteins are integrated into vesicles surrounded by clathrin (clathrin- coated vesicles, CCVs) which are destined for fusion with the early endosome.

Gene Information

Human
Gene Name:	AP2B1
Uniprot:	P63010
Entrez:	163

Family

Belongs to:
adaptor complexes large subunit family

Alternative Names

Adapter-related protein complex 2 beta subunit; Adaptor protein complex AP-2 subunit beta; adaptor-related protein complex 2, beta 1 subunit; ADTB2adaptin, beta 2 (beta); AP105B; AP2-BETA; beta-2-adaptin; beta-adaptin; CLAPB1AP-2 complex subunit beta; Clathrin assembly protein complex 2 beta large chain; clathrin-associated/assembly/adaptor protein, large, beta 1; DKFZp781K0743; Plasma membrane adaptor HA2/AP2 adaptin beta subunit

Molecular Weight

Mass (kDA):
104.553 kDA

Genomic Context

Human
Location:	17q12
Sequence:	17; NC_000017.11 (35587265..35726413)

Subcellular Localizations

Cell membrane. Membrane, coated pit; Peripheral membrane protein; Cytoplasmic side. AP-2 appears to be excluded from internalizing CCVs and to disengage from sites of endocytosis seconds before internalization of the nascent CCV.

Diseases

• Malignant Neoplasms
• Stomach Neoplasms
• Malignant Neoplasm Of Stomach
• Ear Inflammation
• Malignant Neoplasm Of Ovary
• Otitis Media

• Ovarian Neoplasm

Interacting Proteins

• AFF4
• AP1M2
• AP2M1
• Ap2m1
• KPNA2

• LDLRAP1
• MEA1
• MLH1
• Necap1
• SLC25A6

• Tgfbr1
• THAP1
• TXN2
• U2AF1

Pathways

• Cell Junction Assembly
• Cell Proliferation
• Integrin-mediated Signaling Pathway
• Epithelial Cell Proliferation
• Regulation Of Epithelial Cell Proliferation

PTMs

• Acetylation

• Phosphoprotein

For details, visit:
bosterbio.com/bosterbio-gene-info-cards/AP2B1

Boster Bio: Best Uses Of The AP2B1 Marker

This article will discuss the Boster Bio: AP2B1Marker, its gene infographics, as well as the clinical applications of the gene. Boster Pipettes can also be used to disperse 0.5 ul through one-ml volumes of aqueous solution. Boster also offers product credits that allow you to share your results with others.

Boster Bio - AP2B1Marker

The cellular protein AP2B1 plays a role in the endocytosis ADAM10 within hippocampal neurons. The beta subunit, which is part of the protein, acts as a scaffolding mechanism for accessory proteins. It recognizes CLASP motif and binds clathrin's heavy chains to promote lattice building. When clathrin attaches on the cell membrane, it replaces CLASPs from Apolib1. This is then positioned to allow for coat assembly.

Gene infographics

AP2B1 has over 6,750 functions that can be grouped into 8 categories. These associations include molecular profile and organism, chemical, functional term, functional term, phenotypes, structural features, cell line, gene, protein, cell type, gene, or chemical. These gene infographics can be used to explore your genetic information. Learn more about this gene by reading the following.

Clinical applications

The circNF1-419 protein was also identified as a gene for neurodegenerative disorders. These findings provide new insights into the regulation this protein, which is also linked with the AP2B1 genome. This gene binds Dynamin-1 to AP2B1. It regulates multiple signaling pathways and requires further investigation.

The biofluid marker is a biofluid marker that represents different pathways upstream or downstream of a-synuclein. This could be used to stratify patients in pathway-specific trials. This biofluid indicator showed a significantly decreased CSF protein profile for both PD, and DLB. The difference was accentuated in both entities by the presence of the GBA variation. These data highlight the pathomechanistic continuum between DLB and PD, which is accelerated by the presence of GBA variants.