AP4E1 Antibodies

AND AP4E1 ELISA kits, AP4E1 Proteins

Many biological assays use antibodies to detect AP4E1, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with AP4E1 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop AP4E1 antibodies...

We validate the specificity of these antibodies to AP4E1 by testing them on tissues known to express AP4E1 positively and negatively. Browse below to find the AP4E1 antibody that suites your experiment. We have 0 of these antibodies and many publications and validation images.

If you cannot find antibodies that fit your needs, contact us for making custom antibodies. We have a full suite of custom antibody services covering from research to diagnostic and therapeutic applications.

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AP4E1 Infographic by Boster Bio

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AP4E1 Overview

Facts about AP-4 complex subunit epsilon-1.

AP4E1 3D structure. Source: alphafold

AP-4 complex subunit epsilon-1 (AP4E1)

Component of the adaptor protein complex 4 (AP-4). Adaptor protein complexes are vesicle coat components involved both in vesicle formation and cargo selection.

They control the vesicular transport of proteins in different trafficking pathways (PubMed:10066790, PubMed:10436028). AP-4 forms a non clathrin- associated coat on vesicles departing the trans-Golgi network (TGN) and may be involved in the targeting of proteins from the trans-Golgi network (TGN) to the endosomal-lysosomal system.

Gene Information

Human
Gene Name:	AP4E1
Uniprot:	Q9UPM8
Entrez:	23431

Family

Belongs to:

adaptor complexes large subunit family

Alternative Names

Adapter-related protein complex 4 subunit epsilon-1; adaptor-related protein complex 4, epsilon 1 subunit; adaptor-related protein complex AP-4 epsilon; AP-4 adapter complex subunit epsilon; AP-4 complex subunit epsilon-1; AP-4-EPSILON; DKFZp686L12167; Epsilon subunit of AP-4; epsilon-adaptin

Molecular Weight

Mass (kDA):
127.287 kDA

Genomic Context


Human

Location:	15q21.2
Sequence:	15; NC_000015.10 (50908569..51005900)

Tissue Specificity

Widely expressed.

Subcellular Localizations

Golgi apparatus, trans-Golgi network membrane; Peripheral membrane protein.

Diseases

Microcephaly
Cerebral Palsy
Quadriplegic Cerebral Palsy
Muscle Hypotonia
Epilepsy
Growth Retardation
Paraplegia
Brain Diseases
Impairment (finding)

Spastic Paraplegia
Dwarfism
Foot Deformities

Pathways

Brain Development

PTMs

Phosphoprotein

For details, visit:
bosterbio.com/bosterbio-gene-info-cards/AP4E1

References

PMID: 10436028 by Hirst J., et al. Characterization of a fourth adaptor-related protein complex.

PMID: 11409905 by Takatsu H., et al. Similar subunit interactions contribute to assembly of clathrin adaptor complexes and COPI complex: analysis using yeast three-hybrid system.