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- Table of Contents
Facts about Rho guanine nucleotide exchange factor 16.
Guanyl-nucleotide exchange factor of the RHOG GTPase stimulating the exchange of RHOG-associated GDP for GTP.
May play a role in chemotactic cell migration by mediating the activation of RAC1 by EPHA2.May also activate CDC42 and mediate activation of CDC42 by the viral protein HPV16 E6. .
Human | |
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Gene Name: | ARHGEF16 |
Uniprot: | Q5VV41 |
Entrez: | 27237 |
Belongs to: |
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No superfamily |
EPHEXIN4; ephexin-4; GEF16; NBRRho guanine exchange factor (GEF) 16; Rho guanine nucleotide exchange factor (GEF) 16; rho guanine nucleotide exchange factor 16
Mass (kDA):
80.105 kDA
Human | |
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Location: | 1p36.32 |
Sequence: | 1; NC_000001.11 (3454589..3481115) |
Cytoplasm.
PMID: 20679435 by Hiramoto-Yamaki N., et al. Ephexin4 and EphA2 mediate cell migration through a RhoG-dependent mechanism.
PMID: 21139582 by Oliver A.W., et al. The HPV16 E6 binding protein Tip-1 interacts with ARHGEF16, which activates Cdc42.