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Aspm Antibodies
AND Aspm ELISA kits, Aspm Proteins
Many biological assays use antibodies to detect Aspm, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with Aspm in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop Aspm antibodies...
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Aspm Overview
Facts about Abnormal spindle-like microcephaly-associated protein homolog.
Abnormal spindle-like microcephaly-associated protein homolog (Aspm)
Involved in mitotic spindle regulation and coordination of mitotic processes. The function in regulating microtubule dynamics at spindle poles including spindle orientation, astral microtubule density and poleward microtubule flux appear to depend on its association with the katanin complex formed by KATNA1 and KATNB1.
Enhances the microtubule lattice severing activity of KATNA1 by recruiting the katanin complex to microtubules. Can block microtubule minus-end expansion and reversely this function can be improved by the katanin complex (PubMed:28436967).
Gene Information
| Mouse | |
|---|---|
| Gene Name: | Aspm |
| Uniprot: | Q8CJ27 |
| Entrez: | 12316 |
Family
| Belongs to: |
|---|
| No superfamily |
Alternative Names
asp (abnormal spindle) homolog, microcephaly associated (Drosophila); Asp homolog; ASP; Calmbp1; FLJ43117; MCPH5DKFZp686N06184; microcephaly associated (Drosophila); microcephaly, primary autosomal recessive 5
Molecular Weight
Mass (kDA):
364.218 kDA
Genomic Context
| Mouse | |
|---|---|
| Location: | 1|1 E4-F |
| Sequence: | 1; |
Tissue Specificity
Expressed in fetal brain, peripheral nervous system, liver and spleen. In the adult, expressed exclusively in testis, ovary and spleen.
Diseases
- Microcephaly
- Primary Microcephaly
- Malignant Neoplasms
- Neoplasms
- Malignant Paraganglionic Neoplasm
- Glioblastoma
- Dwarfism
- Severe Mental Retardation
- Brain Neoplasms
- Developmental Disabilities
- Medulloblastoma
Pathways
- Mitosis
- Neurogenesis
- Brain Development
- Cell Cycle
- Cell Division
- Cytokinesis
- Cell Proliferation
- Cognition
- Localization
- Pathogenesis
- Chromosome Segregation
- Stem Cell Proliferation
- Cell Death
PTMs
- Methylation
- Demethylation
For details, visit:
bosterbio.com/bosterbio-gene-info-cards/Aspm
bosterbio.com/bosterbio-gene-info-cards/Aspm
References
PMID: 12355089 by Bond J., et al. ASPM is a major determinant of cerebral cortical size.
PMID: 15972725 by Kouprina N., et al. The microcephaly ASPM gene is expressed in proliferating tissues and encodes for a mitotic spindle protein.