Ataxin-1-like Antibodies

AND Atxn1l ELISA kits, Ataxin-1-like Proteins

Many biological assays use antibodies to detect Ataxin-1-like, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with Ataxin-1-like in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop Ataxin-1-like antibodies...

We validate the specificity of these antibodies to Ataxin-1-like by testing them on tissues known to express Atxn1l positively and negatively. Browse below to find the Atxn1l antibody that suites your experiment. We have 0 of these antibodies and many publications and validation images.

If you cannot find antibodies that fit your needs, contact us for making custom antibodies. We have a full suite of custom antibody services covering from research to diagnostic and therapeutic applications.

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Atxn1l Infographic by Boster Bio

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Atxn1l Overview

Facts about Ataxin-1-like.

Ataxin-1-like (Atxn1l)

Chromatin-binding factor that repress Notch signaling in the absence of Notch intracellular domain by acting as a CBF1 corepressor. Binds to the HEY promoter and may assist, together with NCOR2, RBPJ-mediated repression (By similarity).

Can suppress the cytotoxicity of ATXN1 in spinocerebellar ataxia type 1 (SCA1) (PubMed:16121196). In concert with CIC and ATXN1, involved in brain development (PubMed:28288114).

Gene Information

Mouse
Gene Name:	Atxn1l
Uniprot:	P0C7T6
Entrez:	52335

Family

Belongs to:

ATXN1 family

Alternative Names

Ankyrin Repeat And SOCS Box Containing 16; Ankyrin Repeat And SOCS Box-Containing 16; ASB-16

Molecular Weight

Mass (kDA):
73.374 kDA

Genomic Context


Mouse

Location:	8 D3\|8 57.22 cM
Sequence:	8;

Tissue Specificity

Expressed in the cortex and hypothalamus (at protein level). Expressed in neuronal cells. Highly expressed in Purkinje cells of cerebellum.

Diseases

Ataxia
Ataxia, Spinocerebellar
Opca, Menzel Type
Neurodegenerative Disorders
Nervousness
Neuropathology Disease
Congenital Omphalocele

Nerve Degeneration
Hydrocephalus

Pathways

Pathogenesis
Localization

PTMs

Phosphorylation

For details, visit:
bosterbio.com/bosterbio-gene-info-cards/Atxn1l

References

PMID: 16121196 by Mizutani A., et al. Boat, an AXH domain protein, suppresses the cytotoxicity of mutant ataxin-1.

PMID: 17322884 by Bowman A.B., et al. Duplication of Atxn1l suppresses SCA1 neuropathology by decreasing incorporation of polyglutamine-expanded ataxin-1 into native complexes.