Antizyme inhibitor 1 (AZIN1)

Antizyme inhibitor (AZI) protein that positively regulates ornithine decarboxylase (ODC) activity and polyamine uptake. AZI is an enzymatically inactive ODC homolog that counteracts the negative effect of ODC antizymes (AZs) OAZ1, OAZ2 and OAZ3 on ODC activity by competing with ODC for antizyme- binding (PubMed:17900240, PubMed:26305948).

Inhibits antizyme- dependent ODC degradation and releases ODC monomers in their inactive complex with antizymes, resulting in formation of the catalytically active ODC homodimer and restoring polyamine production (PubMed:17900240). .