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- Table of Contents
Antizyme inhibitor 1 Antibodies
AND AZIN1 ELISA kits, Antizyme inhibitor 1 Proteins
Many biological assays use antibodies to detect Antizyme inhibitor 1, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with Antizyme inhibitor 1 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop Antizyme inhibitor 1 antibodies...
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AZIN1 Infographic by Boster Bio
All AZIN1 Products
Product
Figures
Specificity
Applications
Price
Human, Mouse, Rat
IHC, WB
$523
Cat # M07957-1
100 µl
Cat # M07957-1
100 µl
Human, Mouse, Rat
WB
$523
Cat # M07957
100 µl
Cat # M07957
100 µl
Human
$628
Cat # LS051582
20 µg, 100 µg
Cat # LS051582
20 µg, 100 µg
AZIN1 Overview
Facts about Antizyme inhibitor 1.
Antizyme inhibitor 1 (AZIN1)
Antizyme inhibitor (AZI) protein that positively regulates ornithine decarboxylase (ODC) activity and polyamine uptake. AZI is an enzymatically inactive ODC homolog that counteracts the negative effect of ODC antizymes (AZs) OAZ1, OAZ2 and OAZ3 on ODC activity by competing with ODC for antizyme- binding (PubMed:17900240, PubMed:26305948).
Inhibits antizyme- dependent ODC degradation and releases ODC monomers in their inactive complex with antizymes, resulting in formation of the catalytically active ODC homodimer and restoring polyamine production (PubMed:17900240). .
Gene Information
| Human | |
|---|---|
| Gene Name: | AZIN1 |
| Uniprot: | O14977 |
| Entrez: | 51582 |
Family
| Belongs to: |
|---|
| Orn/Lys/Arg decarboxylase class-II family |
Alternative Names
antizyme inhibitor 1; AZI; OAZIMGC691; OAZINEC 4.1.1.17; ODC1L; Ornithine decarboxylase antizyme inhibitorMGC3832
Molecular Weight
Mass (kDA):
49.535 kDA
Genomic Context
| Human | |
|---|---|
| Location: | 8q22.3 |
| Sequence: | 8; NC_000008.11 (102826302..102864200, complement) |
Tissue Specificity
Expressed in liver.
Subcellular Localizations
Nucleus.
Diseases
- Neoplasms
- Malignant Neoplasms
- Hepatitis
- Hepatitis C
- Liver Cirrhosis
- Hepatitis C, Chronic
- Hypoxia
- Fibrosis
- Malignant Paraganglionic Neoplasm
- Liver Diseases
- Disease Of Adrenal Medulla
- Neoplasm Metastasis
Interacting Proteins
- OAZ3
Pathways
- Transport
- Cell Proliferation
- Localization
- Cell Growth
- Polyamine Homeostasis
- Centrosome Duplication
- Regulation Of Cell Cycle
- Secretory Pathway
- Polyamine Transport
- Immune Response
- Dna Methylation
- Protein Secretion
PTMs
For details, visit:
bosterbio.com/bosterbio-gene-info-cards/AZIN1
bosterbio.com/bosterbio-gene-info-cards/AZIN1
References
PMID: 9349715 by Koguchi K., et al. Cloning and sequencing of a human cDNA encoding ornithine decarboxylase antizyme inhibitor.
PMID: 17900240 by Kanerva K., et al. Human ornithine decarboxylase paralogue (ODCp) is an antizyme inhibitor but not an arginine decarboxylase.