Arachidonate 12-lipoxygenase, epidermal-type (Alox12e)

Non-heme iron-containing dioxygenase that probably catalyzes the stereo-specific peroxidation of free and esterified polyunsaturated fatty acids producing a spectrum of bioactive lipid mediators. May preferentially convert arachidonic acid to (12S)-hydroperoxyeicosatetraenoic acid/(12S)-HPETE.

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