Bcl-2-like protein 1 Antibodies

Bcl-2-like protein 1 (BCL2L1)

Potent inhibitor of cell death. Inhibits activation of caspases.

Appears to regulate cell death by blocking the voltage- dependent anion channel (VDAC) by binding to it and preventing the release of the caspase activator, CYC1, from the mitochondrial membrane. Also functions as a regulator of G2 checkpoint and progression to cytokinesis during mitosis.

Gene Information

Human
Gene Name:	BCL2L1
Uniprot:	Q07817
Entrez:	598

Family

Belongs to:
Bcl-2 family

Alternative Names

Apoptosis regulator Bcl-X; bcl2-L-1; BCL2-like 1; bcl-2-like protein 1; BCLXBCL2LBcl-X; BclxL; Bcl-xL; BCL-XL/S; BCLXS; bcl-xS; DKFZp781P2092

Molecular Weight

Mass (kDA):
26.049 kDA

Genomic Context

Human
Location:	20q11.21
Sequence:	20; NC_000020.11 (31664452..31723963, complement)

Tissue Specificity

Bcl-X(S) is expressed at high levels in cells that undergo a high rate of turnover, such as developing lymphocytes. In contrast, Bcl-X(L) is found in tissues containing long-lived postmitotic cells, such as adult brain.

Subcellular Localizations

[Isoform Bcl-X(L)]: Mitochondrion inner membrane. Mitochondrion outer membrane. Mitochondrion matrix. Cytoplasmic vesicle, secretory vesicle, synaptic vesicle membrane. Cytoplasm, cytosol. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Nucleus membrane; Single-pass membrane protein; Cytoplasmic side. After neuronal stimulation, translocates from cytosol to synaptic vesicle and mitochondrion membrane in a calmodulin-dependent manner (By similarity). Localizes to the centrosome when phosphorylated at Ser-49.

Diseases

• Malignant Neoplasms
• Neoplasms
• Carcinoma
• Leukemia
• Malignant Paraganglionic Neoplasm
• Lymphoma
• Mammary Neoplasms
• Cell Transformation, Neoplastic
• Malignant Neoplasm Of Breast
• Myeloid Leukemia
• Adenocarcinoma
• Prostatic Neoplasms
• Malignant Neoplasm Of Prostate

• Ischemia
• Liver Carcinoma
• Nervousness
• Inflammation
• Malignant Tumor Of Colon
• Neoplasm Metastasis
• Colonic Neoplasms

Interacting Proteins

• BAD
• Bad
• BAK1
• BAX
• BBC3

• Bbc3
• BCL2L11
• BECN1
• BID
• BIK

• BMF
• CYCS
• Gimap3
• Gimap5
• HRK

• MTOR
• NLRP1
• RTL10
• SIVA1
• SPNS1

• TP53
• Tp53
• TP53BP2

Pathways

• Cell Death
• Cell Cycle
• Induction Of Apoptosis
• Programmed Cell Death
• Cell Proliferation
• Cell Growth
• Pathogenesis
• Localization
• Cell Cycle Arrest
• Drug Resistance
• Apoptotic Process
• Secretion
• Sensitization

• Rna Interference
• Cell Activation
• Regeneration
• Immune Response
• Cell Differentiation
• Release Of Cytochrome C From Mitochondria
• Transport

PTMs

• Cleavage
• Phosphorylation
• Dephosphorylation
• Phosphorothioation
• Reduction
• Deamidation
• Ubiquitination
• Acetylation
• Methylation
• Oxidation

• Glycosylation
• Myristoylation
• Prenylation
• Nitrosylation
• Hydroxylation
• Biotinylation
• Sumoylation
• Demethylation
• Amidation
• Deglutathionylation

Research Areas

• Apoptosis
• Cancer
• Tumor Suppressors

For details, visit:
bosterbio.com/bosterbio-gene-info-cards/BCL2L1

Best Uses Of The BCL2L1 Marker

In this article, we will examine Boster Bio's brand new Anti-Human Bcl-XL DyLight(r) with 550 conjugated Bcl2L1 Marker as well as the Picokine ELISA platform, and secondary and primary antibodies for research. These instruments can be used to determine the levels of protein expression of samples. We will also talk about our Picokine ELISA platform and its numerous benefits.

Boster Bio's Anti-Human Bcl-XL DyLight(r) 550 conjugated Bcl2L1 Marker

The Boster Bio Anti-Human BclXl DyLight(r) Antibody 550 conjugate to BCL2L1 reacts with human. This BCL2L1 marker has been specifically designed to detect human Bcl-xL. The Bcl-XL protein acts as the main regulator of cell death. It blocks caspases and regulates the progression from the G2 checkpoint to cytokinesis throughout mitosis. Bcl-XL(L) also regulates presynaptic and neurotransmitter release and synaptic clusters. It also improves mitochondrial ATP availability and regulates endocy.

The Bcl-XL gene encodes the human protein Bcl-XL. The members of the BCL-2 family are heterodimers and homodimers. They act as pro and anti-apoptotic regulators. The BCL2L1 gene is located on human chromosomes, where it is located on the cell surface.

Boster Bio's Picokine ELISA platform

Biological assays that detect Bcl-2-like proteins 1 are made up of antibodies that react with various animal samples. Boster Bio created Bcl-2L1 antibodies made from mouse and rabbit samples. This protein functions as a G2 checkpoint regulator and a regulator for the progression from mitosis into the process of cytokinesis.

Boster Bio's primary as well as secondary antibodies are available to conduct research

The Boster Bio anti-Bcl XS/BCL2L1 antibodies are tested in the Western blot test to detect the protein in cells. This antibody is compatible in all tissues including human mice, rat, and mouse. The anti-BCL2L1 antibody is highly effective in the detection of both BCL2L1 and ANXA4 expression.

The BH3 domain is made up of 15 amino acids. Seven amino acids are not conserved between BCL2L1 and BCL2. Functional conversion failed to identify the specific amino acid that triggered the inhibitory effect. The inhibitory capacity of BCL2L1 could instead depend on the protein's overall structure and interaction. The presence of a functional domain could also play a role in the inhibition.

In addition to its function in controlling cell proliferation and survival, BCL2L1 also suppresses FUNDC1-mediated mitophagy. Further study of the BCL2L1-PGAM5 -FUNDC1 relationship will help understand the role of this protein in human disease. Boster Bio's antibodies to BCL2L1 are being used in a new study. They are being used to pinpoint the causes of apoptosis in the human brain.