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- Table of Contents
BOK Antibodies
AND BOK ELISA kits, BOK Proteins
Many biological assays use antibodies to detect BOK, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with BOK in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop BOK antibodies...
Designing a Western blot for BOK? The guide has the expected band size, antibodies backed by real blot images, the controls to run alongside, and protocols taken from published papers.
Open the BOK Western Blot GuideBOK Infographic by Boster Bio
All BOK Products
Product
Figures
Specificity
Applications
Price
Human, Mouse, Rat
ELISA, Flow Cytometry, WB
$370
Cat # A05577-3
100 µg/vial
Cat # A05577-3
100 µg/vial
BOK Overview
Facts about Bcl-2-related ovarian killer protein.
Bcl-2-related ovarian killer protein (BOK)
Isoform 1: Apoptosis regulator that functions through distinct apoptotic signaling pathways (PubMed:27076518, PubMed:15102863, PubMed:20673843). Plays a roles as pro-apoptotic protein that positively regulates intrinsic apoptotic process in a BAX- and BAK1-dependent fashion or in a BAX- and BAK1-independent way (PubMed:27076518, PubMed:15102863).
In response to endoplasmic reticulum stress promotes mitochondrial apoptosis through downstream BAX/BAK1 activation and positive regulation of PERK-mediated unfolded protein response (By similarity). Activates apoptosis independently of heterodimerization with survival- promoting BCL2 and BCL2L1 through induction of mitochondrial outer membrane permeabilization, in a BAX- and BAK1-independent fashion, in response to inhibition of ERAD-proteasome degradation system, resulting in cytochrome c release (PubMed:27076518).
Gene Information
| Human | |
|---|---|
| Gene Name: | BOK |
| Uniprot: | Q9UMX3 |
| Entrez: | 666 |
Family
| Belongs to: |
|---|
| Bcl-2 family |
Alternative Names
bcl2-L-9; BCL2L9bcl-2-related ovarian killer protein; Bcl-2-like protein 9; BCL2-related ovarian killer; BOK; BOKL; hBOK; MGC4631
Molecular Weight
Mass (kDA):
23.28 kDA
Genomic Context
| Human | |
|---|---|
| Location: | 2q37.3 |
| Sequence: | 2; NC_000002.12 (241558745..241574131) |
Tissue Specificity
Expressed mainly in oocytes; weak expression in granulosa cells of the developing follicles. In adult human ovaries, expressed in granulosa cells at all follicular stages, but expression in primordial/primary follicles granulosa cell is stronger than in secondary and antral follicles.
Subcellular Localizations
[Isoform 1]: Mitochondrion membrane; Single-pass membrane protein. Endoplasmic reticulum membrane; Single-pass membrane protein. Mitochondrion inner membrane. Cytoplasm. Nucleus. Mitochondrion. Endoplasmic reticulum. Mitochondrion outer membrane. Early endosome membrane. Recycling endosome membrane. Nucleus outer membrane. Golgi apparatus, cis-Golgi network membrane. Golgi apparatus, trans-Golgi network membrane. Membrane. Nuclear and cytoplasmic compartments in the early stages of apoptosis and during apoptosis it associates with mitochondria (PubMed:19942931). In healthy cells, associates lo
Diseases
- Malignant Neoplasms
- Neoplasms
- Malignant Neoplasm Of Breast
- Prostatic Neoplasms
- Mammary Neoplasms
- Malignant Neoplasm Of Prostate
- Retinoblastoma
- Atresia
- Lymphoma
- Ovarian Neoplasm
- Pre-eclampsia
- Hyperplasia
- Adenoma
Pathways
- Cell Death
- Cell Cycle
- Cell Proliferation
- Transport
- Induction Of Apoptosis
- Localization
- Pathogenesis
- Cell Cycle Arrest
- Cell Killing
- Cell Growth
- Cell Adhesion
- Programmed Cell Death
- Aging
PTMs
- Cleavage
Research Areas
- Apoptosis
For details, visit:
bosterbio.com/bosterbio-gene-info-cards/BOK
bosterbio.com/bosterbio-gene-info-cards/BOK
References
PMID: 11034351 by Zhang H., et al. Evolutionarily conserved Bok proteins in the Bcl-2 family.
PMID: 15775999 by Soleymanlou N., et al. A novel Mtd splice isoform is responsible for trophoblast cell death in pre-eclampsia.