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- Table of Contents
BRMS1 Antibodies
AND BRMS1 ELISA kits, BRMS1 Proteins
Many biological assays use antibodies to detect BRMS1, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with BRMS1 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop BRMS1 antibodies...
Designing a Western blot for BRMS1? The guide has the expected band size, antibodies backed by real blot images, the controls to run alongside, and protocols taken from published papers.
Open the BRMS1 Western Blot GuideBRMS1 Infographic by Boster Bio
All BRMS1 Products
Product
Figures
Specificity
Applications
Price
Human, Mouse, Rat
WB
$523
Cat # M10900
100 µl
Cat # M10900
100 µl
BRMS1 Overview
Facts about Breast cancer metastasis-suppressor 1.
Breast cancer metastasis-suppressor 1 (BRMS1)
Transcriptional repressor. Down-regulates transcription activation by NF-kappa-B by promoting the deacetylation of RELA in'Lys-310'.
Promotes HDAC1 binding to promoter regions. Down- regulates expression of anti-apoptotic genes that are controlled by NF-kappa-B.
Gene Information
| Human | |
|---|---|
| Gene Name: | BRMS1 |
| Uniprot: | Q9HCU9 |
| Entrez: | 25855 |
Family
| Belongs to: |
|---|
| BRMS1 family |
Alternative Names
breast cancer metastasis suppressor 1; breast cancer metastasis-suppressor 1; DKFZP564A063
Molecular Weight
Mass (kDA):
28.461 kDA
Genomic Context
| Human | |
|---|---|
| Location: | 11q13.2 |
| Sequence: | 11; NC_000011.10 (66337333..66345125, complement) |
Tissue Specificity
Expression levels are higher in term placentas than in early placentas. Low levels of expression observed in normal pregnancies and in molar pregnancies.
Subcellular Localizations
Nucleus. Cytoplasm. Predominantly nuclear.
Diseases
- Neoplasm Metastasis
- Malignant Neoplasms
- Malignant Neoplasm Of Breast
- Neoplasms
- Mammary Neoplasms
- Carcinoma
- Melanoma
- Cell Invasion
- Lung Neoplasms
- Primary Neoplasm
- Neoplasm Invasiveness
- Metastatic Malignant Neoplasm To The Lymph Node
Interacting Proteins
- CEP70
- DNAJB6
- HDAC1
- HDAC2
- HDAC4
- HDAC5
- HDAC6
- NMI
- SMARCE1
- SUDS3
Pathways
- Localization
- Methylation
- Cell Growth
- Cell Adhesion
- Cell Migration
- Chromatin Remodeling
- Cellular Localization
- Anoikis
- Angiogenesis
- Transport
- Nuclear Export
- Cell Cycle
- Secretion
PTMs
- Methylation
- Phosphorylation
- Acetylation
Research Areas
- Cell Cycle and Replication
For details, visit:
bosterbio.com/bosterbio-gene-info-cards/BRMS1
bosterbio.com/bosterbio-gene-info-cards/BRMS1
References
PMID: 10850410 by Seraj M.J., et al. Functional evidence for a novel human breast carcinoma metastasis suppressor, BRMS1, encoded at chromosome 11q13.
PMID: 12414911 by Janneau J.-L., et al. Transcriptional expression of genes involved in cell invasion and migration by normal and tumoral trophoblast cells.