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- Table of Contents
Facts about Serine/threonine-protein kinase BRSK1.
Also regulates neuron polarization by mediating phosphorylation of WEE1 in'Ser-642' in post-mitotic neurons, leading to down-regulate WEE1 action in polarized neurons. In neurons, localizes to synaptic vesicles and plays a role in neurotransmitter release, possibly by phosphorylating RIMS1.
Human | |
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Gene Name: | BRSK1 |
Uniprot: | Q8TDC3 |
Entrez: | 84446 |
Belongs to: |
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protein kinase superfamily |
BR serine/threonine kinase 1; EC 2.7.11; EC 2.7.11.1; FLJ43009; KIAA1811BR serine/threonine-protein kinase 1; protein kinase SAD1A; SAD1 kinase; SAD1; Serine/threonine-protein kinase SAD-B
Mass (kDA):
85.087 kDA
Human | |
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Location: | 19q13.42 |
Sequence: | 19; NC_000019.10 (55283997..55312562) |
Widely expressed, with highest levels in brain and testis. Protein levels remain constant throughout the cell cycle.
Cytoplasm. Nucleus. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Cell junction, synapse. Cell junction, synapse, presynaptic active zone. Cytoplasmic vesicle, secretory vesicle, synaptic vesicle. Nuclear in the absence of DNA damage. Translocated to the nucleus in response to UV- or MMS-induced DNA damage (By similarity).
The BRSK1 cell based ELISA kits is a good choice for quick, high-throughput monitoring BRSK1 expression in cultured tissues. This kit allows you screen for the effects activators or treatments on BRSK1. Note that this kit is only available with Boster products, so you need to purchase the entire kit from Boster Bio.
The Boster Bio BRSK1 Cell-based ELISA Kit is a suitable choice for determining the presence of BRSK1 in various cell types. It can detect this kinase in the group of protein kinases such as CDK9/cyclin T1, PKCbII and ERK/MAPKFGFR.
BRSK1 (B-1), a monoclonal, high-quality antibody that is suitable for the detection and analysis of protein from a mouse/rat, is available. It is available both in multiple-conjugated or non-conjugated formats. BRSK1 is essential to the phosphorylation or dephosphorylation proteins and is involved in many cellular functions.
PMID: 14976552 by Lizcano J.M., et al. LKB1 is a master kinase that activates 13 kinases of the AMPK subfamily, including MARK/PAR-1.
PMID: 15150265 by Lu R., et al. Human SAD1 kinase is involved in UV-induced DNA damage checkpoint function.