BRSK1 Antibodies

Serine/threonine-protein kinase BRSK1 (BRSK1)

Serine/threonine-protein kinase that plays a key role in polarization of neurons and centrosome duplication. Following phosphorylation and activation by STK11/LKB1, acts as a key regulator of polarization of cortical neurons, probably by mediating phosphorylation of microtubule-associated proteins such as MAPT/TAU in'Thr-529' and'Ser-579'.

Also regulates neuron polarization by mediating phosphorylation of WEE1 in'Ser-642' in post-mitotic neurons, leading to down-regulate WEE1 action in polarized neurons. In neurons, localizes to synaptic vesicles and plays a role in neurotransmitter release, possibly by phosphorylating RIMS1.

Gene Information

Human
Gene Name:	BRSK1
Uniprot:	Q8TDC3
Entrez:	84446

Family

Belongs to:
protein kinase superfamily

Alternative Names

BR serine/threonine kinase 1; EC 2.7.11; EC 2.7.11.1; FLJ43009; KIAA1811BR serine/threonine-protein kinase 1; protein kinase SAD1A; SAD1 kinase; SAD1; Serine/threonine-protein kinase SAD-B

Molecular Weight

Mass (kDA):
85.087 kDA

Genomic Context

Human
Location:	19q13.42
Sequence:	19; NC_000019.10 (55283997..55312562)

Tissue Specificity

Widely expressed, with highest levels in brain and testis. Protein levels remain constant throughout the cell cycle.

Subcellular Localizations

Cytoplasm. Nucleus. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Cell junction, synapse. Cell junction, synapse, presynaptic active zone. Cytoplasmic vesicle, secretory vesicle, synaptic vesicle. Nuclear in the absence of DNA damage. Translocated to the nucleus in response to UV- or MMS-induced DNA damage (By similarity).

Diseases

• Neoplasms
• Sclerosis
• Premature Menopause
• Tuberous Sclerosis
• Melanoma
• Malignant Neoplasm Of Breast
• Nervous System Disorder
• Ovarian Failure, Premature
• Epilepsy
• Autistic Disorder

• Gastric Outlet Obstruction
• Cardiovascular Diseases
• Malignant Neoplasms
• Nervousness

Pathways

• Menopause
• Cell Cycle
• Localization
• Centrosome Duplication
• Menarche
• Brain Development
• Aging
• Mitosis
• Synaptic Transmission
• Energy Homeostasis
• Cell Cycle Arrest

• Regeneration
• Cell Division
• Translation
• Dna Damage Checkpoint
• Cell Growth
• Pathogenesis

PTMs

• Phosphorylation

• Dephosphorylation

• Palmitoylation

For details, visit:
bosterbio.com/bosterbio-gene-info-cards/BRSK1

Best Uses Of The BRSK1 Marker

The BRSK1 cell based ELISA kits is a good choice for quick, high-throughput monitoring BRSK1 expression in cultured tissues. This kit allows you screen for the effects activators or treatments on BRSK1. Note that this kit is only available with Boster products, so you need to purchase the entire kit from Boster Bio.

BRSK1 Cell - Based ELISA Test Kit

The Boster Bio BRSK1 Cell-based ELISA Kit is a suitable choice for determining the presence of BRSK1 in various cell types. It can detect this kinase in the group of protein kinases such as CDK9/cyclin T1, PKCbII and ERK/MAPKFGFR.

BRSK1 Antibody Picoband (tm)

BRSK1 (B-1), a monoclonal, high-quality antibody that is suitable for the detection and analysis of protein from a mouse/rat, is available. It is available both in multiple-conjugated or non-conjugated formats. BRSK1 is essential to the phosphorylation or dephosphorylation proteins and is involved in many cellular functions.