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- Table of Contents
Bcl11a Antibodies
AND Bcl11a ELISA kits, Bcl11a Proteins
Many biological assays use antibodies to detect Bcl11a, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with Bcl11a in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop Bcl11a antibodies...
Designing a Western blot for Bcl11a? The guide has the expected band size, antibodies backed by real blot images, the controls to run alongside, and protocols taken from published papers.
Open the BCL11A Western Blot GuideBcl11a Infographic by Boster Bio
All Bcl11a Products
Product
Figures
Specificity
Applications
Price
Human, Mouse, Rat
Flow Cytometry, IF, IHC, ICC, WB
$370
Cat # M00741
100 μl
Cat # M00741
100 μl
Bcl11a Overview
Facts about B-cell lymphoma/leukemia 11A.
B-cell lymphoma/leukemia 11A (Bcl11a)
Functions as a myeloid and B-cell proto-oncogene.
May play important roles in leukemogenesis and hematopoiesis.A vital element in lymphopoiesis, is needed for B-cell formation in fetal liver. May function as a modulator of the transcriptional repression activity of ARP1.
Gene Information
| Mouse | |
|---|---|
| Gene Name: | Bcl11a |
| Uniprot: | Q9QYE3 |
| Entrez: | 14025 |
Family
| Belongs to: |
|---|
| No superfamily |
Alternative Names
B-cell CLL/lymphoma 11A (zinc finger protein) isoform 2; B-cell CLL/lymphoma 11A (zinc finger protein); B-cell CLL/lymphoma 11A; B-cell lymphoma/leukemia 11A; BCL11A B-cell CLL/lymphoma 11A (zinc finger protein) isoform 1; BCL-11A; BCL11A-S; BCL11A-XL; C2H2-type zinc finger protein; COUP-TF-interacting protein 1; CTIP1ecotropic viral integration site 9; ecotropic viral integration site 9 homolog; Ecotropic viral integration site 9 protein homolog; EVI-9; EVI9FLJ34997; HBFQTL5; KIAA1809BCL11A-L; Zinc finger protein 856; ZNF856FLJ10173
Molecular Weight
Mass (kDA):
83.855 kDA
Genomic Context
| Mouse | |
|---|---|
| Location: | 11|11 A3.2 |
| Sequence: | 11; |
Tissue Specificity
Isoforms are expressed in a tissue-specific fashion. Isoforms 1, isoform 2, and isoform 3 are expressed at similar levels in testis, kidney and spleen. Isoform 1 is expressed in the stomach, and isoform 2 is expressed exclusively in the lung. Overexpression following proviral integration in hematopoietic cells results in the generation of myeloid leukemia.
Diseases
- Anemia, Sickle Cell
- Leukemia
- Beta Thalassemia
- Lymphoma
- Malignant Neoplasms
- Neoplasms
- Anemia
- B-cell Lymphomas
- Lymphoid Leukemia
- Chronic Lymphocytic Leukemia
- Thalassemia
- Chromosomal Translocation
- Diabetes Mellitus
Pathways
- Pathogenesis
- Cell Development
- Gene Silencing
- Interphase
- Cell Proliferation
- Secretion
- Cell Fate Specification
- Translation
- Insulin Secretion
- Localization
- Methylation
- Innervation
- Cell Activation
PTMs
- Deacetylation
- Phosphorylation
Research Areas
- Apoptosis
- Cancer
- Inhibitors, Activators and Regulators
- Transcription Factors and Regulators
- Tumor Suppressors
For details, visit:
bosterbio.com/bosterbio-gene-info-cards/Bcl11a
bosterbio.com/bosterbio-gene-info-cards/Bcl11a
References
PMID: 10757802 by Nakamura T., et al. Evi9 encodes a novel zinc finger protein that physically interacts with BCL6, a known human B-cell proto-oncogene product.
PMID: 10744719 by Avram D., et al. Isolation of a novel family of C(2)H(2) zinc finger proteins implicated in transcriptional repression mediated by chicken ovalbumin upstream promoter transcription factor (COUP-TF) orphan nuclear receptors.