C8A Antibodies

AND C8A ELISA kits, C8A Proteins

Many biological assays use antibodies to detect C8A, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with C8A in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop C8A antibodies...

We validate the specificity of these antibodies to C8A by testing them on tissues known to express C8A positively and negatively. Browse below to find the C8A antibody that suites your experiment. We have 1 of these antibodies and many publications and validation images.

If you cannot find antibodies that fit your needs, contact us for making custom antibodies. We have a full suite of custom antibody services covering from research to diagnostic and therapeutic applications.

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C8A Infographic by Boster Bio

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Anti-C8 alpha Antibody

Western Blot analysis of 1, mouse-kidney 2, mouse-heart cells using primary antibody diluted at 1:500 (4°C overnight)

Human, Mouse

ELISA, WB

$380
Cat # A05720
100ul

C8A Overview

Facts about Complement component C8 alpha chain.

C8A 3D structure. Source: alphafold

Complement component C8 alpha chain (C8A)

Constituent of the membrane attack complex (MAC) which plays an integral role in the innate and adaptive immune response by forming pores in the plasma membrane of target cells. C8A inserts into the target membrane, but does not form pores alone.

Gene Information

Human
Gene Name:	C8A
Uniprot:	P07357
Entrez:	731

Family

Belongs to:

complement C6/C7/C8/C9 family

Alternative Names

complement component 8, alpha polypeptide; complement component C8 alpha chain

Molecular Weight

Mass (kDA):
65.163 kDA

Genomic Context


Human

Location:	1p32.2
Sequence:	1; NC_000001.11 (56854796..56918223)

Subcellular Localizations

Secreted. Cell membrane; Multi-pass membrane protein. Secreted as soluble protein. Inserts into the cell membrane of target cells.

Diseases

Meningitis
Infective Disorder
Influenza
Sclerosis
Neuroblastoma
Aneurysm
Prion Diseases
Encephalopathy, Bovine Spongiform
Pseudorabies
Meningococcal Infections
Liver Carcinoma
Multiple Sclerosis

Aortic Aneurysm
Endometriosis, Site Unspecified
Encephalopathies
Acute-phase Reaction
Encephalitis
Inflammation
Alzheimer's Disease

Pathways

Complement Activation
Disease Resistance
Neuroprotection
Dna Replication
Acute-phase Response
Immune Response
Pathogenesis

Viral Replication
Localization

PTMs

Phosphorylation
Glycosylation
Acetylation

Oxidation
Methylation
Deamidation

For details, visit:
bosterbio.com/bosterbio-gene-info-cards/C8A

References

PMID: 2820471 by Rao A.G., et al. Complementary DNA and derived amino acid sequence of the alpha subunit of human complement protein C8: evidence for the existence of a separate alpha subunit messenger RNA.

PMID: 7759071 by Michelotti G.A., et al. Genomic organization of human complement protein C8 alpha and further examination of its linkage to C8 beta.