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- Table of Contents
Facts about Calcium-dependent secretion activator 1.
Regulates catecholamine loading of DCVs. May specifically mediate the Ca(2+)-dependent exocytosis of large dense-core vesicles (DCVs) and other dense-core vesicles by acting as a PtdIns(4,5)P2-binding protein which acts at prefusion step after ATP-dependent priming and participates in DCVs-membrane fusion.
Human | |
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Gene Name: | CADPS |
Uniprot: | Q9ULU8 |
Entrez: | 8618 |
Belongs to: |
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No superfamily |
Ca++-dependent secretion activator; CADPS1; Calcium-dependent activator protein for secretion 1; calcium-dependent secretion activator 1; CAPS-1; CAPS1Ca2+-dependent secretion activator; CAPSCa2+-dependent activator protein for secretion; KIAA1121Ca2+-regulated cytoskeletal protein
Mass (kDA):
152.786 kDA
Human | |
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Location: | 3p14.2 |
Sequence: | 3; NC_000003.12 (62398348..62875865, complement) |
Specifically expressed in neural and endocrine secretory tissues. Expressed in brain and pancreas and at low level in heart. Also expressed in fetal heart, cerebellum, cerebral cortex, medulla, occipital pole, frontal and temporal lobes, and putamen, as well as weak expression in spinal cord.
Cell junction, synapse. Cytoplasmic vesicle, secretory vesicle, neuronal dense core vesicle membrane; Peripheral membrane protein. Membrane-associated to vesicles. Strongly enriched in synaptic fractions. Preferentially binds to dense core vesicles but not to synaptic vesicles. Binds phosphoinosides, with a strong selectivity for PtdIns(4,5)P2 over PtdIns(3,4,5)P3. Probably localizes to different vesicles compared to CADPS2.
PMID: 12659812 by Cisternas F.A., et al. Cloning and characterization of human CADPS and CADPS2, new members of the Ca2+-dependent activator for secretion protein family.
PMID: 9289490 by Ann K., et al. Novel Ca2+-binding protein (CAPS) related to UNC-31 required for Ca2+-activated exocytosis.