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Protein CASC3 Antibodies
AND CASC3 ELISA kits, Protein CASC3 Proteins
Many biological assays use antibodies to detect Protein CASC3, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with Protein CASC3 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop Protein CASC3 antibodies...
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CASC3 Overview
Facts about Protein CASC3.
Protein CASC3 (CASC3)
Core part of the splicing-dependent multiprotein exon junction complex (EJC) deposited at splice junctions on mRNAs. The EJC is a dynamic structure consisting of core proteins and several peripheral nuclear and cytoplasmic related things that join the complicated only transiently either through EJC assembly or through subsequent mRNA metabolism.
The EJC marks the place of the exon-exon intersection at the mature mRNA for the gene expression machinery and the core elements stay bound to spliced mRNAs through all stages of mRNA metabolism thereby influencing downstream processes including nuclear mRNA export, subcellular mRNA localization, translation efficiency and nonsense-mediated mRNA decay (NMD). Stimulates the ATPase and RNA- helicase activities of EIF4A3.
Gene Information
| Human | |
|---|---|
| Gene Name: | CASC3 |
| Uniprot: | O15234 |
| Entrez: | 22794 |
Family
| Belongs to: |
|---|
| CASC3 family |
Alternative Names
barentsz; Btz; cancer susceptibility candidate 3; Cancer susceptibility candidate gene 3 protein; metastatic lymph node 51; Metastatic lymph node gene 51 protein; MLN 51; MLN51BTZ; Protein barentsz; protein CASC3
Molecular Weight
Mass (kDA):
76.278 kDA
Genomic Context
| Human | |
|---|---|
| Location: | 17q21.1 |
| Sequence: | 17; NC_000017.11 (40140506..40172172) |
Tissue Specificity
Widely expressed. Overexpressed in breast cancers and metastasis, as well as in gastric cancers.
Subcellular Localizations
Cytoplasm. Cytoplasm, perinuclear region. Nucleus. Nucleus speckle. Cytoplasm, Stress granule. Cytoplasm, Cytoplasmic ribonucleoprotein granule. Cell projection, dendrite. Shuttles between the nucleus and the cytoplasm in a XPO1/CRM1-dependent manner. Transported to the cytoplasm as part of the exon junction complex (EJC) bound to mRNA (PubMed:15166247). In nuclear speckles, colocalizes with MAGOH. Under stress conditions, colocalizes with FMR1 and TIA1, but not MAGOH and RBM8A EJC core factors, in cytoplasmic stress granules (PubMed:17652158). In the dendrites of hippocampal neurons, localize
Diseases
- Malignant Neoplasms
- Malignant Neoplasm Of Breast
- Malignant Paraganglionic Neoplasm
- Carcinoma
- Arthritis
- Mammary Neoplasms
- Hyperplasia
- Rheumatoid Arthritis
- Stomach Neoplasms
- Neoplasm Metastasis
- Nervous System Disorder
- Autoimmune Diseases
Interacting Proteins
- EIF4A3
- MAGOH
Pathways
- Localization
- Translation
- Pathogenesis
- Transport
- Protein Splicing
- Brain Development
- Neuron Development
- Metaphase
- Mrna Transport
- Cell Cycle Arrest
- Rna Localization
PTMs
- ADP-ribosylation
Research Areas
- Cancer
For details, visit:
bosterbio.com/bosterbio-gene-info-cards/CASC3
bosterbio.com/bosterbio-gene-info-cards/CASC3
References
PMID: 7490069 by Tomasetto C.L., et al. Identification of four novel human genes amplified and overexpressed in breast carcinoma and localized to the q11-q21.3 region of chromosome 17.
PMID: 12080473 by Degot S.F., et al. Metastatic lymph node 51, a novel nucleo-cytoplasmic protein overexpressed in breast cancer.