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Plays a role during muscle differentiation; P-TEFB complex interacts with MYOD1; this tripartite complex promotes the transcriptional activity of MYOD1 through its CDK9-mediated phosphorylation and binds the chromatin of promoters and enhancers of muscle-specific genes; this event correlates with hyperphosphorylation of the CTD domain of RNA pol II (By similarity). Additionally, enhances MYOD1-dependent transcription through interaction with PKN1 (PubMed:16331689).
|Sequence:||2; NC_000002.12 (134918810..134959342)|
Cytoplasm, perinuclear region. Nucleus. Nucleus in differentiating cells.