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- Table of Contents
CD1A Antibodies
AND CD1A ELISA kits, CD1A Proteins
Many biological assays use antibodies to detect CD1A, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with CD1A in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop CD1A antibodies...
Designing a Western blot for CD1A? The guide has the expected band size, antibodies backed by real blot images, the controls to run alongside, and protocols taken from published papers.
Open the CD1A Western Blot GuideCD1A Infographic by Boster Bio
All CD1A Products
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CD1A Overview
Facts about T-cell surface glycoprotein CD1a.
T-cell surface glycoprotein CD1a (CD1A)
Antigen-presenting protein that binds self and non-self lipid and glycolipid antigens and presents them to T-cell receptors on natural killer T-cells. .
Gene Information
| Human | |
|---|---|
| Gene Name: | CD1A |
| Uniprot: | P06126 |
| Entrez: | 909 |
Family
| Belongs to: |
|---|
| No superfamily |
Alternative Names
CD1; CD1a antigen; CD1A antigen, a polypeptide; CD1a molecule; CD1a; cluster of differentiation 1 A; cortical thymocyte antigen CD1A; differentiation antigen CD1-alpha-3; epidermal dendritic cell marker CD1a; FCB6; hTa1 thymocyte antigen; HTA1; R4; T6; T-cell surface antigen T6/Leu-6; T-cell surface glycoprotein CD1a
Molecular Weight
Mass (kDA):
37.077 kDA
Genomic Context
| Human | |
|---|---|
| Location: | 1q23.1 |
| Sequence: | 1; NC_000001.11 (158248336..158258269) |
Tissue Specificity
Expressed on cortical thymocytes, epidermal Langerhans cells, dendritic cells, on certain T-cell leukemias, and in various other tissues.
Subcellular Localizations
Cell membrane; Single-pass type I membrane protein. Membrane raft; Single-pass type I membrane protein. Endosome membrane; Single-pass type I membrane protein. Subject to intracellular trafficking between the cell membrane and endosomes (PubMed:11231314). Localizes to cell surface lipid rafts (PubMed:18178838).
Diseases
- Histiocytosis
- Autoimmune Reaction
- Infective Disorder
- Guillain-barre Syndrome
- Immunologic Deficiency Syndromes
- Histiocytosis, Langerhans-cell
- Autoimmune Diseases
- Leukemia
- Neoplasms
- Group B Streptococcal Infection
- Polyradiculoneuropathy, Chronic Inflammatory Demyelinating
- Demyelinating Polyneuropathy
Interacting Proteins
- B2M
Pathways
- Pathogenesis
- Cell Activation
- Cell Proliferation
- Cytolysis
- Aging
- Glycosylation
- Complement-dependent Cytotoxicity
- Inflammatory Response
- Cell Division
- Mrna Splicing
PTMs
- Disulfide bond
Research Areas
- Dendritic Cell Markers
- Immunology
For details, visit:
bosterbio.com/bosterbio-gene-info-cards/CD1A
bosterbio.com/bosterbio-gene-info-cards/CD1A
References
PMID: 2701945 by Aruffo A., et al. Expression of cDNA clones encoding the thymocyte antigens CD1a, b, c demonstrates a hierarchy of exclusion in fibroblasts.
PMID: 2447586 by Martin L.H., et al. Structure and expression of the human thymocyte antigens CD1a, CD1b, and CD1c.