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CD6 Antibodies
AND CD6 ELISA kits, CD6 Proteins
Many biological assays use antibodies to detect CD6, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with CD6 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop CD6 antibodies...
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CD6 Infographic by Boster Bio
All CD6 Products
Product
Figures
Specificity
Applications
Price
Human soluble CD6 ELISA Kit PicoKine®
1 Citations 7 Q&As
Human
ELISA
$499
Cat # EK1221
96 wells/kit, with removable strips.
Cat # EK1221
96 wells/kit, with removable strips.
Mouse
ELISA
$499
Cat # EK1287
96 wells/kit, with removable strips.
Cat # EK1287
96 wells/kit, with removable strips.
Human
ELISA
$499
Cat # FEK1221
96 wells/kit, with removable strips.
Cat # FEK1221
96 wells/kit, with removable strips.
Human
Flow Cytometry, IP, IHC-P, WB
$291
Cat # M03913-2
0.1 mg
Cat # M03913-2
0.1 mg
CD6 Overview
Facts about T-cell differentiation antigen CD6.
T-cell differentiation antigen CD6 (CD6)
Cell adhesion molecule that mediates cell-cell contacts and modulates T-cell responses through its interaction with ALCAM/CD166 (PubMed:15048703, PubMed:15294938, PubMed:16352806, PubMed:16914752, PubMed:24945728, PubMed:24584089). Contributes to signaling cascades triggered by activation of the TCR/CD3 complex (PubMed:24584089).
Functions as costimulatory molecule; promotes T-cell activation and proliferation (PubMed:15294938, PubMed:16352806, PubMed:16914752). Contributes to the formation and maturation of the immunological synapse (PubMed:15294938, PubMed:16352806).
Gene Information
| Human | |
|---|---|
| Gene Name: | CD6 |
| Uniprot: | P30203 |
| Entrez: | 923 |
Family
| Belongs to: |
|---|
| No superfamily |
Alternative Names
CD6 antigenFLJ44171; CD6 molecule; CD6; T12; Tp120; TP120T-cell differentiation antigen CD6
Molecular Weight
Mass (kDA):
71.801 kDA
Genomic Context
| Human | |
|---|---|
| Location: | 11q12.2 |
| Sequence: | 11; NC_000011.10 (60971678..61020377) |
Tissue Specificity
Detected on thymocytes (PubMed:15294938). Detected on peripheral blood T-cells (PubMed:15048703, PubMed:16352806). Detected on natural killer (NK) cells (PubMed:16352806). Soluble CD6 is detected in blood serum (at protein level) (PubMed:17601777). Detected in spleen, thymus, appendix, lymph node and peripheral blood leukocytes (PubMed:9013954). Expressed by thymocytes, mature T-cells, a subset of B-cells known as B-1 cells, and by some cells in the brain.
Subcellular Localizations
Cell membrane; Single-pass type I membrane protein. Detected at the immunological synapse, i.e, at the contact zone between antigen-presenting dendritic cells and T-cells (PubMed:15294938, PubMed:16352806). Colocalizes with the TCR/CD3 complex at the immunological synapse (PubMed:15294938).; [Soluble CD6]: Secreted. The origins of the secreted form are not clear, but it might be created by proteolytic shedding of the ectodomain.
Diseases
- Tissue Adhesions
- Leukemia
- Graft-vs-host Disease
- Neoplasms
- Lymphoid Leukemia
- Malignant Neoplasms
- Lymphoma
- Sclerosis
- Chronic Lymphocytic Leukemia
- Acute Lymphocytic Leukemia
- Autoimmune Reaction
- Malignant Paraganglionic Neoplasm
- Inflammation
Interacting Proteins
- ALCAM
- LCP2
- LGALS1
- LGALS3
Pathways
- Cell Adhesion
- Cell Activation
- T Cell Activation
- Cell Proliferation
- Immune Response
- T Cell Proliferation
- Localization
- Leukocyte Differentiation
- Pathogenesis
- Lymphocyte Activation
- Cell Death
- Cell Differentiation
- Regulation Of T Cell Activation
PTMs
- Phosphorylation
- Cleavage
- Glycosylation
- Carboxylation
For details, visit:
bosterbio.com/bosterbio-gene-info-cards/CD6
bosterbio.com/bosterbio-gene-info-cards/CD6
References
PMID: 9013954 by Bowen M.A., et al. Structure and chromosomal location of the human CD6 gene: detection of five human CD6 isoforms.
PMID: 1919444 by Aruffo A., et al. The lymphocyte glycoprotein CD6 contains a repeated domain structure characteristic of a new family of cell surface and secreted proteins.
1 Publications of Boster CD6 Antibodies & ELISA Kits
- PubMed ID: 10.1136/jitc-2019-000172, Multifaceted effects of soluble human CD6 in experimental cancer models
*More publications can be found for each product on its corresponding product page