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- Table of Contents
CD74 Antibodies
AND CD74 ELISA kits, CD74 Proteins
Many biological assays use antibodies to detect CD74, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with CD74 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop CD74 antibodies...
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CD74 Infographic by Boster Bio
All CD74 Products
Product
Figures
Specificity
Applications
Price
Human
Flow Cytometry, IF, IHC, ICC, WB
$370
Cat # M01340-2
100 μl
Cat # M01340-2
100 μl
Anti-CD74 Antibody
1 Citations
Human, Mouse, Rat
Flow Cytometry, IF, IHC, ICC
$370
Cat # A01340-2
100 μg/vial
Cat # A01340-2
100 μg/vial
Human
ELISA, Flow Cytometry, IF, IHC, WB
$370
Cat # A01340-4
100 μg/vial
Cat # A01340-4
100 μg/vial
Cynomolgus monkey, Human, Mouse
ELISA, Flow Cytometry, Functional Assay, Kinetics
$486
Cat # M01340-4
100 μg
Cat # M01340-4
100 μg
CD74 Overview
Facts about HLA class II histocompatibility antigen gamma chain.
HLA class II histocompatibility antigen gamma chain (CD74)
Plays a critical role in MHC class II antigen processing by stabilizing peptide-free class II alpha/beta heterodimers in a complex soon after their synthesis and directing transport of the complex in the endoplasmic reticulum into the endosomal/lysosomal system where the antigen processing and binding of antigenic peptides to MHC class II takes place. Serves as cell surface receptor for the cytokine MIF.
.
Gene Information
| Human | |
|---|---|
| Gene Name: | CD74 |
| Uniprot: | P04233 |
| Entrez: | 972 |
Family
| Belongs to: |
|---|
| No superfamily |
Alternative Names
CD74 antigen (invariant polypeptide of major histocompatibility complex, classII antigen-associated); CD74 antigen; CD74 molecule, major histocompatibility complex, class II invariant chain; CD74; CLIP; DHLAG; DHLAGgamma chain of class II antigens; HLA class II histocompatibility antigen gamma chain; HLADG; HLA-DR antigens-associated invariant chain; HLA-DR-gamma; Ia antigen-associated invariant chain; Ia-associated invariant chain; Ia-gamma; Ii; INVG34; MHC HLA-DR gamma chain; p33
Molecular Weight
Mass (kDA):
33.516 kDA
Genomic Context
| Human | |
|---|---|
| Location: | 5q33.1 |
| Sequence: | 5; NC_000005.10 (150400041..150412936, complement) |
Subcellular Localizations
Cell membrane; Single-pass type II membrane protein. Endoplasmic reticulum membrane. Golgi apparatus, trans-Golgi network. Endosome. Lysosome. Transits through a number of intracellular compartments in the endocytic pathway. It can either undergo proteolysis or reach the cell membrane.
Diseases
- Neoplasms
- Malignant Neoplasms
- Lymphoma
- Inflammation
- B-cell Lymphomas
- Carcinoma
- Tissue Adhesions
- Malignant Paraganglionic Neoplasm
- Leukemia
- Immunologic Deficiency Syndromes
- Chronic Lymphocytic Leukemia
- Autoimmune Reaction
Interacting Proteins
- CD44
- CXCR4
- EIF3E
- HSPA1A
- KPNB1
Pathways
- Pathogenesis
- Cell Proliferation
- Immune Response
- Secretion
- Angiogenesis
- Cell Adhesion
- Inflammatory Response
- Cell Death
- Cell Growth
- Transport
- Cell Activation
- Cell Migration
- Cell Differentiation
PTMs
- Phosphorylation
- Cleavage
- Biotinylation
Research Areas
- Immunology
For details, visit:
bosterbio.com/bosterbio-gene-info-cards/CD74
bosterbio.com/bosterbio-gene-info-cards/CD74
References
PMID: 6324166 by Claesson L., et al. cDNA clone for the human invariant gamma chain of class II histocompatibility antigens and its implications for the protein structure.
PMID: 6586420 by Strubin M., et al. The complete sequence of the mRNA for the HLA-DR-associated invariant chain reveals a polypeptide with an unusual transmembrane polarity.