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- Table of Contents
CDC20 Antibodies
AND CDC20 ELISA kits, CDC20 Proteins
Many biological assays use antibodies to detect CDC20, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with CDC20 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop CDC20 antibodies...
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CDC20 Infographic by Boster Bio
All CDC20 Products
Product
Figures
Specificity
Applications
Price
Human, Mouse, Rat
Flow Cytometry, IF, IHC, IHC-F, ICC, WB
$370
Cat # A00382-1
100 μg/vial
Cat # A00382-1
100 μg/vial
CDC20 Overview
Facts about Cell division cycle protein 20 homolog.
Cell division cycle protein 20 homolog (CDC20)
Required for full ubiquitin ligase activity of the anaphase promoting complex/cyclosome (APC/C) and may confer substrate specificity upon the complex. Is regulated by MAD2L1: in metaphase the MAD2L1-CDC20-APC/C ternary complex is inactive and in anaphase the CDC20-APC/C binary complex is active in degrading substrates.
The CDC20-APC/C complex positively regulates the formation of synaptic vesicle clustering at active zone to the presynaptic membrane in postmitotic neurons. CDC20-APC/C-induced degradation of NEUROD2 causes presynaptic differentiation.
Gene Information
| Human | |
|---|---|
| Gene Name: | CDC20 |
| Uniprot: | Q12834 |
| Entrez: | 991 |
Family
| Belongs to: |
|---|
| WD repeat CDC20/Fizzy family |
Alternative Names
CDC20 cell division cycle 20 homolog (S. cerevisiae); CDC20 cell division cycle 20 homolog; cell division cycle 20 homolog (S. cerevisiae); cell division cycle protein 20 homolog; MGC102824; p55CDCS. cerevisiae, homolog)
Molecular Weight
Mass (kDA):
54.723 kDA
Genomic Context
| Human | |
|---|---|
| Location: | 1p34.2 |
| Sequence: | 1; NC_000001.11 (43358981..43363203) |
Subcellular Localizations
Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Cytoplasm, cytoskeleton, spindle pole.
Diseases
- Malignant Neoplasms
- Neoplasms
- Aneuploidy
- Cell Transformation, Neoplastic
- Genomic Instability
- Carcinoma
- Mammary Neoplasms
- Malignant Paraganglionic Neoplasm
- Malignant Neoplasm Of Breast
- Lung Neoplasms
- Leukemia
- Polyploidy
- Adenocarcinoma
Interacting Proteins
- ANAPC4
- Axin2
- BUB1B
- CDC27
- MAD2L1
- MAD2L2
Pathways
- Mitosis
- Cell Cycle
- Anaphase
- Spindle Assembly
- Spindle Checkpoint
- Spindle Assembly Checkpoint
- Proteolysis
- Metaphase
- Chromosome Segregation
- Cell Division
- Exit From Mitosis
- Meiosis
- Localization
PTMs
- Phosphorylation
- Ubiquitination
- Dephosphorylation
- Cleavage
Research Areas
- Cell Cycle and Replication
- Core ESC-Like Genes
- Stem Cell Markers
For details, visit:
bosterbio.com/bosterbio-gene-info-cards/CDC20
bosterbio.com/bosterbio-gene-info-cards/CDC20
References
PMID: 7513050 by Weinstein J., et al. A novel mammalian protein, p55CDC, present in dividing cells is associated with protein kinase activity and has homology to the Saccharomyces cerevisiae cell division cycle proteins Cdc20 and Cdc4.
PMID: 9811605 by Kramer E.R., et al. Activation of the human anaphase-promoting complex by proteins of the CDC20/Fizzy family.