Serine/threonine-protein kinase MRCK alpha (CDC42BPA)

Serine/threonine-protein kinase which is an important downstream effector of CDC42 and plays a role in the regulation of cytoskeleton reorganization and cell migration (PubMed:15723050, PubMed:9418861, PubMed:9092543). Regulates actin cytoskeletal reorganization through phosphorylation of PPP1R12C and MYL9/MLC2 (PubMed:21457715).

In concert with MYO18A and LURAP1, is involved in regulating lamellar actomyosin retrograde flow that's imperative to cell protrusion and migration (PubMed:18854160). Phosphorylates: PPP1R12A, LIMK1 and LIMK2 (PubMed:11340065, PubMed:11399775).