Complement factor I Antibodies

AND CFI ELISA kits, Complement factor I Proteins

Many biological assays use antibodies to detect Complement factor I, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with Complement factor I in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop Complement factor I antibodies...

We validate the specificity of these antibodies to Complement factor I by testing them on tissues known to express CFI positively and negatively. Browse below to find the CFI antibody that suites your experiment. We have 2 of these antibodies and many publications and validation images.

If you cannot find antibodies that fit your needs, contact us for making custom antibodies. We have a full suite of custom antibody services covering from research to diagnostic and therapeutic applications.

Designing a Western blot for Complement factor I? The guide has the expected band size, antibodies backed by real blot images, the controls to run alongside, and protocols taken from published papers.

Open the CFI Western Blot Guide

CFI Infographic by Boster Bio

All CFI Products

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Product

Figures

Specificity

Applications

Price

Anti-Factor I/CFI Antibody Picoband®

Western blot analysis of Factor I using anti-Factor I antibody (PB9935)

Flow Cytometry analysis of U-87 cells using anti-Factor I antibody (PB9935)

Flow Cytometry analysis of HEPG2 cells using anti-Factor I antibody (PB9935)

Human, Rat

Flow Cytometry, IHC, ICC, WB

$370
Cat # PB9935
100 μg/vial

Factor I (CFI) (NM_000204) Human Over-expression Lysate

Human

$960
Cat # LS003426
20 µg, 100 µg

CFI Overview

Facts about Complement factor I.

CFI 3D structure. Source: alphafold

Complement factor I (CFI)

Responsible for cleaving the alpha-chains of C4b and C3b in the presence of the cofactors C4-binding protein and factor H respectively.
.

Gene Information

Human
Gene Name:	CFI
Uniprot:	P05156
Entrez:	3426

Family

Belongs to:

peptidase S1 family

Alternative Names

AHUS3; C3b Inactivator; C3B/C4B inactivator; C3BINA; C3b-inactivator; CFI; complement component I; complement control protein factor I; complement factor I heavy chain; Complement Factor I; EC 3.4.21; EC 3.4.21.45; FIC3b-INA; I factor (complement); IF; KAF; Konglutinogen-activating factor; light chain of factor I

Molecular Weight

Mass (kDA):
65.75 kDA

Genomic Context


Human

Location:	4q25
Sequence:	4; NC_000004.12 (109730982..109802040, complement)

Tissue Specificity

Plasma.

Subcellular Localizations

Secreted, extracellular space. Secreted.

Diseases

Expressed Emotion
Schizophrenia
Depressive Disorder
Hemolytic-uremic Syndrome
Uremia Syndrome
Coronary Artery Disease
Anxiety Disorders
Coronary Occlusion
Hemolytic Uremic Syndrome, Atypical
Stenosis
Neoplasms
Dental Fluorosis, Acquired

Malignant Neoplasms
Coronary Heart Disease
Ischemia
Mental Disorders
Age Related Macular Degeneration
Myocardial Ischemia
Anemia

Pathways

Pathogenesis
Complement Activation
Chemotaxis
Insemination
Neutrophil Chemotaxis
Lactation
Secretion
Localization
Inflammatory Response
Translation
Mating
Transport
Aging

Hypersensitivity
Virulence
Antigenic Variation
Angiogenesis
Cell Migration
Coagulation
Monocyte Chemotaxis

PTMs

Cleavage
Phosphorylation
Sulphation

Carboxylation
Glycosylation
Decarboxylation

Dephosphorylation

For details, visit:
bosterbio.com/bosterbio-gene-info-cards/CFI

References

PMID: 2954545 by Catterall C.F., et al. Characterization of primary amino acid sequence of human complement control protein factor I from an analysis of cDNA clones.

PMID: 2956252 by Goldberger G., et al. Human complement factor I: analysis of cDNA-derived primary structure and assignment of its gene to chromosome 4.