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- Table of Contents
Facts about Cbp/p300-interacting transactivator 1.
Stimulates estrogen-dependent transactivation activity mediated by estrogen receptors signaling; stabilizes the interaction of nitric oxide ESR1 and histone acetyltransferase EP300. Induces transcription from estrogen-responsive promoters and protection against cell death.
Human | |
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Gene Name: | CITED1 |
Uniprot: | Q99966 |
Entrez: | 4435 |
Belongs to: |
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CITED family |
cbp/p300-interacting transactivator 1; Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain1,MSG1Melanocyte-specific protein 1; melanocyte-specific gene 1
Mass (kDA):
19.896 kDA
Human | |
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Location: | Xq13.1 |
Sequence: | X; NC_000023.11 (72301638..72307157, complement) |
Expressed only in melanocytes and testis.
Nucleus. Cytoplasm. Shuttles between the nucleus and the cytoplasm by a nuclear export signal and (NES) in a CRM1-dependent manner.
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The CITED1 molecule plays an important role for the malignant phenotypes of K1 cells. Interestingly, knockdowns of CITED1 significantly reduced cell growth and tumorigenic potency. Thus, it is possible that CITED1 plays a central oncogenic role in PTC. The CITED1 marker is a promising candidate for targeted drug discovery.
CITED1 belongs to the nuclear protein group that regulates transcription factors. High background staining is caused by antibodies against CITED1. However, recombinant proteins antibodies can overcome this problem. These antibodies can be combined with other markers and are particularly useful in papillary thyroid carcinomas. CITED1 cannot be used for all types or tumors.
The trophoblast lineages show high expression of the CITED1 marker. Cited1 plays a crucial role in trophoblast differentiation, both in vitro as in vivo. This protein is involved in regulating the BMP signaling pathway. Therefore, understanding its role in trophoblast differentiation is crucial for the development of the embryo. It is crucial to identify the appropriate CITED1 antigen.
Invasion of cells and migration is inhibited by downregulations in CITED1. Transfected cells show lower migration rates and invasion. Data are presented as means + standard deviations. This marker can be used in many applications, including tumor biology as well as cellular development. This marker can be used in many other applications. Further research is needed to understand its potential role as a treatment for thyroid cancer. This protein inhibits tumor development and is of interest to researchers studying thyroid cancer.
Overexpression of CITED1 within ESC has been shown to disrupt self-renewal. Overexpression of CITED1 can also cause phenotypic consequences in other mouse ESC line lines. In addition to disrupting the ESC, Cited1 also activates trophoblast-associated genes. This is one of many promising therapeutic applications for CITED1.
PMID: 8901575 by Shioda T., et al. msg1, a novel melanocyte-specific gene, encodes a nuclear protein and is associated with pigmentation.
PMID: 9707553 by Shioda T., et al. Transcriptional activating activity of Smad4: roles of SMAD hetero- oligomerization and enhancement by an associating transactivator.