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- Table of Contents
Facts about C-type lectin domain family 2 member D.
Inhibits bone resorption (PubMed:14753741). Modulates the launch of interferon-gamma (PubMed:15104121).
Human | |
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Gene Name: | CLEC2D |
Uniprot: | Q9UHP7 |
Entrez: | 29121 |
Belongs to: |
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No superfamily |
CLAXLLT-1; CLEC2D; C-type lectin domain family 2 member D; C-type lectin domain family 2, member D; C-type lectin related f; Lectin-like NK cell receptor; Lectin-like transcript 1; LLT1; LLT1Osteoclast inhibitory lectin; OCIL; OCILmember D
Mass (kDA):
21.849 kDA
Human | |
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Location: | 12p13.31 |
Sequence: | 12; NC_000012.12 (9669713..9699553) |
Detected in peripheral blood leukocytes, osteoblasts, lymph node, thymus and spleen. Isoform 1, isoform 2 and isoform 4 are expressed in T- and B-lymphocytes, and at lower levels in NK cells. They are also expressed in B-cell lines and LPS-matured monocyte-derived dendritic cells.
Cell membrane; Single-pass type II membrane protein.; [Isoform 2]: Endoplasmic reticulum.; [Isoform 4]: Endoplasmic reticulum.
PMID: 10541800 by Boles K.S., et al. Cloning of a new lectin-like receptor expressed on human NK cells.
PMID: 14753741 by Hu Y.S., et al. Isolation of a human homolog of osteoclast inhibitory lectin that inhibits the formation and function of osteoclasts.