CMTR1 Infographic
Cap-specific mRNA (nucleoside-2'-O-)-methyltransferase 1 Info At a glance, species: Human
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Cap-specific mRNA (nucleoside-2'-O-)-methyltransferase 1 (CMTR1)
S-adenosyl-L-methionine-dependent methyltransferase that mediates mRNA cap1 two'-O-ribose methylation into the 5'-cap structure of mRNAs. Methylates the ribose of the first nucleotide of a m(7)GpppG-capped mRNA and small nuclear RNA (snRNA) to produce m(7)GpppRm (cap1).
Displays a preference for cap0 transcripts. Cap1 modification is connected to high levels of translation.
Gene Information
| Human | |
|---|---|
| Gene Name: | CMTR1 |
| Uniprot: | Q8N1G2 |
| Entrez: | 23070 |
Family
| Belongs to: |
|---|
| No superfamily |
Alternative Names
Cap-specific mRNA (nucleoside-2'-O-)-methyltransferase 1
Molecular Weight
Mass (kDA):
95.321 kDA
Genomic Context
| Human | |
|---|---|
| Location: | 6p21.2 |
| Sequence: | 6; NC_000006.12 (37433214..37482844) |
Subcellular Localizations
Nucleus.
PTMs
- Acetylation
For details, visit:
bosterbio.com/bosterbio-gene-info-cards/CMTR1
bosterbio.com/bosterbio-gene-info-cards/CMTR1
References
PMID: 12743294 by Geiss G.K., et al. Gene expression profiling of the cellular transcriptional network regulated by alpha/beta interferon and its partial attenuation by the hepatitis C virus nonstructural 5A protein.
PMID: 12743306 by Guerra S., et al. Cellular gene expression survey of vaccinia virus infection of human HeLa cells.
