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Its scaffolding function suggests its interaction with the catalytic complex module and varied RNA-binding proteins mediating the complex recruitment to selected mRNA 3'UTRs. Involved in degradation of AU-rich element (ARE)-containing mRNAs probably via association with ZFP36.
|Sequence:||16; NC_000016.10 (58519951..58629826, complement)|
Strongly expressed in brain, heart, thymus, spleen, kidney, liver, placenta and lung. Weakly expressed in skeletal muscle and colon.
Cytoplasm, P-body. Nucleus. NANOS2 promotes its localization to P-body.