CCR4-NOT transcription complex subunit 1 (CNOT1)

Scaffolding component of the CCR4-NOT complex that's one of the major cellular mRNA deadenylases and is connected to various cellular processes including bulk mRNA degradation, miRNA- mediated repression, translational repression during translational initiation and general transcription regulation. Additional complex functions may be a result of its influence on mRNA expression.

Its scaffolding function suggests its interaction with the catalytic complex module and varied RNA-binding proteins mediating the complex recruitment to selected mRNA 3'UTRs. Involved in degradation of AU-rich element (ARE)-containing mRNAs probably via association with ZFP36.