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Its association with NOTCH1 boosts NOTCH1 activation through the released notch intracellular domain (NICD) and subsequent translocation to the nucleus. Involved in motor coordination (By similarity).
|Sequence:||3; NC_000003.12 (978021..1404217)|
Expressed in nervous system. Highly expressed in cerebellum. Expressed at intermediate level in thalamus, subthalamic nucleus. Weakly expressed in corpus callosum, caudate nucleus and spinal cord.
Cell membrane; Lipid-anchor, GPI-anchor.