Cttnbp2 Infographic
Cortactin-binding protein 2 Info At a glance, species: Mouse
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Cortactin-binding protein 2 (Cttnbp2)
Regulates the dendritic spine distribution of CTTN/cortactin in hippocampal neurons, and thus controls dendritic spinogenesis and dendritic spine maintenance. .
Gene Information
| Mouse | |
|---|---|
| Gene Name: | Cttnbp2 |
| Uniprot: | B9EJA2 |
| Entrez: | 30785 |
Family
| Belongs to: |
|---|
| No superfamily |
Alternative Names
C7orf8; cortactin binding protein 2; cortactin-binding protein 2; CortBP2; CORTBP2Orf4; FLJ34229; KIAA1758MGC104579
Molecular Weight
Mass (kDA):
178.774 kDA
Genomic Context
| Mouse | |
|---|---|
| Location: | 6|6 A2 |
| Sequence: | 6; |
Tissue Specificity
Isoform 2 is predominantly expressed in brain (at protein level). In the brain, expressed at high levels in hypothalamus and striatum and at lower levels in cerebellum and cortex.
Diseases
- Cystic Fibrosis
- Fibrosis
- Curvature Of Spine
- Glioma
- Cartilaginous Exostosis
- Malignant Neoplasms
- Cavernous Hemangioma Of Brain
- Neoplasms
- Cerebrovascular Accident
- Psychomotor Disorders
- Embryonic Mosaic
- Dermatofibrosarcoma
Pathways
- Chromosome Organization
- Localization
PTMs
- Methylation
For details, visit:
bosterbio.com/bosterbio-gene-info-cards/Cttnbp2
bosterbio.com/bosterbio-gene-info-cards/Cttnbp2
References
PMID: 22262902 by Chen Y.K., et al. Cortactin-binding protein 2 modulates the mobility of cortactin and regulates dendritic spine formation and maintenance.
PMID: 23015759 by Chen Y.K., et al. CTTNBP2, but not CTTNBP2NL, regulates dendritic spinogenesis and synaptic distribution of the striatin-PP2A complex.