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- Table of Contents
Cullin-5 Antibodies
AND CUL5 ELISA kits, Cullin-5 Proteins
Many biological assays use antibodies to detect Cullin-5, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with Cullin-5 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop Cullin-5 antibodies...
Designing a Western blot for Cullin-5? The guide has the expected band size, antibodies backed by real blot images, the controls to run alongside, and protocols taken from published papers.
Open the CUL5 Western Blot GuideCUL5 Infographic by Boster Bio
All CUL5 Products
Product
Figures
Specificity
Applications
Price
CUL5 Overview
Facts about Cullin-5.
Cullin-5 (CUL5)
Core component of multiple SCF-like ECS (Elongin-Cullin 2/5-SOCS-box protein) E3 ubiquitin-protein ligase complexes, which mediate the ubiquitination and subsequent proteasomal degradation of target proteins. As a scaffold protein may contribute to catalysis through positioning of the substrate and the ubiquitin- conjugating enzyme.
The functional specificity of the E3 ubiquitin-protein ligase complex is based upon the variable substrate recognition component. ECS(SOCS1) appears to direct ubiquitination of JAK2.
Gene Information
| Human | |
|---|---|
| Gene Name: | CUL5 |
| Uniprot: | Q93034 |
| Entrez: | 8065 |
Family
| Belongs to: |
|---|
| cullin family |
Alternative Names
CUL-5; cullin 5; VACM1Cullin-5 (vasopressin-activated calcium-mobilizing receptor-1); VACM-1cullin-5; Vasopressin-activated calcium-mobilizing receptor 1; Vasopressin-activated calcium-mobilizing receptor-1
Molecular Weight
Mass (kDA):
90.955 kDA
Genomic Context
| Human | |
|---|---|
| Location: | 11q22.3 |
| Sequence: | 11; NC_000011.10 (108008733..108107766) |
Diseases
- Hiv Infections
- Immunologic Deficiency Syndromes
- Neoplasms
- Malignant Neoplasms
- Nervousness
- Tissue Adhesions
- Inflammation
- Acquired Immunodeficiency Syndrome
- Disease Of Adrenal Medulla
- Malignant Neoplasm Of Breast
- Von Hippel-lindau Syndrome
- Leukemia
Interacting Proteins
- ARIH2
- ASB1
- ASB2
- ASB6
- ASB7
- CCNDBP1
- ERBB2
- GOLGA2
- HSPA1A
- RBX1
Pathways
- Viral Replication
- Cell Cycle
- Cell Growth
- Cell Adhesion
- Localization
- Transport
- Proteolysis
- Cell Proliferation
- Conjugation
- Pathogenesis
- Rna Interference
- Cell Activation
- Reverse Transcription
PTMs
- Ubiquitination
- Phosphorylation
Research Areas
- Cancer
For details, visit:
bosterbio.com/bosterbio-gene-info-cards/CUL5
bosterbio.com/bosterbio-gene-info-cards/CUL5
References
PMID: 9037604 by Byrd P.J., et al. Identification and analysis of expression of human VACM-1, a cullin gene family member located on chromosome 11q22-23.
PMID: 10230407 by Ohta T., et al. ROC1, a homolog of APC11, represents a family of cullin partners with an associated ubiquitin ligase activity.