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- Table of Contents
Facts about Cholesterol 24-hydroxylase.
Involved in the turnover of cholesterol.
It converts cholesterol to 24S-hydroxycholesterol and, to a lesser extent, 25-hydroxycholesterol.Has also action with xenobiotic compounds, such as clotrimazole. .
Human | |
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Gene Name: | CYP46A1 |
Uniprot: | Q9Y6A2 |
Entrez: | 10858 |
Belongs to: |
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cytochrome P450 family |
CH24H; cholesterol 24-hydroxylase; CYP46CP46; Cytochrome P450 46A1; cytochrome P450, family 46, subfamily A, polypeptide 1; cytochrome P450, subfamily 46 (cholesterol 24-hydroxylase); EC 1.14.13.98
Mass (kDA):
56.821 kDA
Human | |
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Location: | 14q32.2 |
Sequence: | 14; NC_000014.9 (99684262..99727321) |
Expressed in brain. The mRNA was broadly distributed with higher levels in gray matter zones and lower levels in regions rich in white matter. Not detected in fetal sample but its expression increases linearly with age.
Endoplasmic reticulum membrane; Single-pass membrane protein. Microsome membrane; Single-pass membrane protein. Cell junction, synapse, postsynapse. Cell junction, synapse, presynapse. Cell projection, dendrite.
PMID: 10377398 by Lund E.G., et al. cDNA cloning of cholesterol 24-hydroxylase, a mediator of cholesterol homeostasis in the brain.
PMID: 12077124 by Bodin K., et al. Metabolism of 4 beta -hydroxycholesterol in humans.