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Ceacam2 Antibodies
AND Ceacam2 ELISA kits, Ceacam2 Proteins
Many biological assays use antibodies to detect Ceacam2, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with Ceacam2 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop Ceacam2 antibodies...
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Ceacam2 Overview
Facts about Carcinoembryonic antigen-related cell adhesion molecule 2.
Carcinoembryonic antigen-related cell adhesion molecule 2 (Ceacam2)
Controls energy balance and peripheral insulin activity. Involved in the regulation of feeding behaviour especially in the ventromedial nucleus of hypothalamus (VMH) regulation of food intake.
Has a role in the regulation of metabolic rate and insulin sensitivity or resistance via impacts on brown adipogenesis, sympathetic nervous outflow to brown adipose tissue, spontaneous activity and energy expenditure in skeletal muscle. In the event of murine coronavirus (MHV) infection, does probably not serve as functional receptor for the virus.
Gene Information
| Mouse | |
|---|---|
| Gene Name: | Ceacam2 |
| Uniprot: | Q925P2 |
| Entrez: | 26367 |
Family
| Belongs to: |
|---|
| immunoglobulin superfamily |
Alternative Names
Carcinoembryonic antigen-related cell adhesion molecule 2
Molecular Weight
Mass (kDA):
57.202 kDA
Genomic Context
| Mouse | |
|---|---|
| Location: | 7 A3|7 13.87 cM |
| Sequence: | 7; |
Tissue Specificity
Isoform 2 is detected in elongating spermatids within the seminiferous epithelium (at protein level). Expressed in kidney, colon, uterus, gut mononuclear cells, crypt epithelia of intestinal tissues, and to a lesser extent, in spleen. Expressed in brain including VMH, globus pallidus, ventral pallidum, striatum, olfactory bulb and hippocampus. Also detected in rectal carcinoma cell line CMT93. Isoform 2 and isoform 3 are expressed in testis. Isoform 2 is detected in seminiferous tubule, not detected in epididymal spermatozoa. Also not observed on spermatogonia, spermatocytes, round spermatids or somatic Sertoli cells. During stages I-VII of spermatogenesis, detected on the elongating spermatids. At spermiation (stage VIII) and subsequent stages IX-XII, levels are drastically reduced or absent in the seminiferous tubules. Sometimes weakly detected in the apical region of stage-VIII seminiferous epithelium. Isoform 2 level is very low in stomach, kidney, intestine, liver and spleen.
PTMs
- Disulfide bond
For details, visit:
bosterbio.com/bosterbio-gene-info-cards/Ceacam2
bosterbio.com/bosterbio-gene-info-cards/Ceacam2
References
PMID: 8207827 by Nedellec P., et al. Bgp2, a new member of the carcinoembryonic antigen-related gene family, encodes an alternative receptor for mouse hepatitis viruses.
PMID: 11284729 by Han E., et al. Differences in tissue-specific and embryonic expression of mouse Ceacam1 and Ceacam2 genes.