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- Table of Contents
Facts about DAN domain family member 5.
Cystine knot-containing proteins play important roles during development, organogenesis, and tissue growth and differentiation. .
Mouse | |
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Gene Name: | Dand5 |
Uniprot: | Q76LW6 |
Entrez: | 23863 |
Belongs to: |
---|
DAN family |
CER2CRL2; Cerberus 2; Cerberus like-2; cerberus-like 2; Cerberus-like protein 2; CERL2; cerl-2; CKTSF1B3; CKTSF1B3MGC126849; COCO; Cysteine knot superfamily 1, BMP antagonist 3; DAN domain family member 5; DAN domain family, member 5; DAND5; Dante; DTE; FLJ38607; GREM3; GREM3cerberus 2; gremlin-3; SP1
Mass (kDA):
19.772 kDA
Mouse | |
---|---|
Location: | 8|8 C2 |
Sequence: | 8; |
Dand5 can also be detected in a variety biologic assays using antibodies. These antibodies can react with Dand5 protein in a variety samples. Boster Bio has used mouse, rabbit, and other animals as models for the DAND5 marker antibody development. The critical role of cystine knot-containing proteins in development, tissue growth and organogenesis is played by Boster Bio. For example, Cerl-2 is required for the correct L/R body axis.
Boster Bio is a trusted name in the production of high-affinity primary antibody. Boster Bio uses proprietary chemistry and flow cytometry in order to create the highest affinity clones for Diagnostics & Therapeutics. Boster's proprietary chemical blocks the secretion antibodies from B cells while keeping them on the cell walls. After selecting clones with the highest levels of brightness, Boster Bio processes these clones further.
The ELISA kits from Boster can be used in a variety if applications, including detections of hormones and small molecules, oxidative damage, DNA loss, and various cytokines. Boster has successfully validated ELISA kits against diverse samples. Boster's high-affinity primary antibodies are capable of detecting IL-6, IL-8 and IL-10, as well as EGF and cytokines.
Enzyme-linked immunosorbent assays (ELISA) are akin to other immunoassay technologies, with the aim of using specific antibodies to bind a target antigen and a detection system to determine whether it has been successfully bound. High-affinity primary antibody are crucial to increase ELISA sensitivity. Boster Bio has mastered the art of coating plates with high-affinity antibodies, and scientists all over the world trust them.
Both primary and secondary antibodies are often used as core components in experiments and active ingredients for assays. Primary antibodies are used for immunoassays based on their ability of binding antigens. Immunoassays include Western Blotting, immunohistochemistry, histopathology tests, and flow cytometry. Flow cytometry analyzes the percentage of certain types cells in a sample.
Recombinant antibodies have the advantage of preserving the genetic information. By producing recombinant antibodies, Boster Bio ensures that the customer is able to screen the supernatant for three clones and select the best. In addition to ELISA data, the customer will also receive 100 ng of heavy chain plasmid DNA and purified antibody, for testing purposes.
The master regulator of Nodal signaling is the DAND5 variant. Biochemical assays show a decrease of activity in patients who have a non-synonymous gene variant. Patients with this variant are susceptible to multiple phenotypes. These include left isomerism (ventricular septal defect), overriding aorta, right hypertrophy, andpulmonary atresia. DAND5 variants are associated to extreme tetralogyof Fallot.
Boster Bio developed antibodies for many biological tests that detect Dand5 proteins. These antibodies react with Dand5 proteins from a variety animal samples. Boster Bio develops its antibodies using rabbit and mouse cells. This protein plays an important role in tissue growth, organogenesis and development. It also promotes L/R body axis, a critical developmental step. Boster Bio's DAND5 biological assays are therefore sensitive and specific.
Steven Boster lives a life filled with adventure and achievements. Steve Boster was born June 6,1939 and was an accomplished retail manager. He was a U.S. Army soldier and a Concordia Hall student in Staunton. His hard work and dedication are evident in his six grandchildren and his two daughters Natosha Poeck and Crystal Boster. His siblings include brothers Jack Boster and Jack Blanton, as well as his wife, Sandra. Many nieces, nephews, and other relatives survived him.
Steve was a father to his family and would call him first if his car stopped working at 2 a.m. He would be there to fix it, even in sub-freezing conditions. His generosity extended beyond his immediate family and included neighbors as well. The rich history of Steven Boster is full of interesting events that make it difficult not to learn more about the man who was so generous. Below are some interesting facts about Steve Boster.
PMID: 15466485 by Marques S., et al. The activity of the Nodal antagonist Cerl-2 in the mouse node is required for correct L/R body axis.