DCAF8 Antibodies

AND DCAF8 ELISA kits, DCAF8 Proteins

Many biological assays use antibodies to detect DCAF8, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with DCAF8 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop DCAF8 antibodies...

We validate the specificity of these antibodies to DCAF8 by testing them on tissues known to express DCAF8 positively and negatively. Browse below to find the DCAF8 antibody that suites your experiment. We have 2 of these antibodies and many publications and validation images.

If you cannot find antibodies that fit your needs, contact us for making custom antibodies. We have a full suite of custom antibody services covering from research to diagnostic and therapeutic applications.

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DCAF8 Infographic by Boster Bio

All DCAF8 Products

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WDR42A (DCAF8) (NM_015726) Human Recombinant Protein

Coomassie blue staining of purified DCAF8 protein

$1249
Cat # PROTQ5TAQ9
20 µg

WDR42A (DCAF8) (NM_015726) Human Over-expression Lysate

Human

$960
Cat # LS050717
20 µg, 100 µg

DCAF8 Overview

Facts about DDB1- and CUL4-associated factor 8.

DCAF8 3D structure. Source: alphafold

DDB1- and CUL4-associated factor 8 (DCAF8)

May function as a substrate receptor for CUL4-DDB1 E3 ubiquitin-protein ligase complex. .

Gene Information

Human
Gene Name:	DCAF8
Uniprot:	Q5TAQ9
Entrez:	50717

Family

Belongs to:

WD repeat DCAF8 family

Alternative Names

DDB1 and CUL4 associated factor 8; DDB1- and CUL4-associated factor 8; DKFZp781G1096; FLJ35857; H326MGC117276; MGC118891; MGC99640; WD repeat domain 42A; WD repeat-containing protein 42A; WDR42A

Molecular Weight

Mass (kDA):
66.852 kDA

Genomic Context


Human

Location:	1q23.2
Sequence:	1; NC_000001.11 (160215720..160262549, complement)

Subcellular Localizations

Nucleus. Cytoplasm. It shuttles between the nucleus and the cytoplasm. Nuclear import is mediated by KPNA1 and KPNB1 under the regulation of nuclear GTPase RAN. Nuclear export to the cytoplasm is XPO1 dependent.

Diseases

Giant axonal neuropathy 2, autosomal dominant (GAN2)

Interacting Proteins

DDB1
KPNA1
MDFI
PRMT1
RBPMS

SUV39H1
THAP1
TRIM54
TRIM63

PTMs

Methylation

Phosphoprotein

For details, visit:
bosterbio.com/bosterbio-gene-info-cards/DCAF8

References

PMID: 16949367 by Jin J., et al. A family of diverse Cul4-Ddb1-interacting proteins includes Cdt2, which is required for S phase destruction of the replication factor Cdt1.

PMID: 16964240 by Angers S., et al. Molecular architecture and assembly of the DDB1-CUL4A ubiquitin ligase machinery.