DCDC2 Antibodies

AND DCDC2 ELISA kits, DCDC2 Proteins

Many biological assays use antibodies to detect DCDC2, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with DCDC2 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop DCDC2 antibodies...

We validate the specificity of these antibodies to DCDC2 by testing them on tissues known to express DCDC2 positively and negatively. Browse below to find the DCDC2 antibody that suites your experiment. We have 2 of these antibodies and many publications and validation images.

If you cannot find antibodies that fit your needs, contact us for making custom antibodies. We have a full suite of custom antibody services covering from research to diagnostic and therapeutic applications.

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DCDC2 Infographic by Boster Bio

All DCDC2 Products

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DCDC2 (NM_016356) Human Recombinant Protein

Coomassie blue staining of purified DCDC2 protein

$1249
Cat # PROTQ9UHG0
20 µg

DCDC2 (NM_016356) Human Over-expression Lysate

Human

$628
Cat # LS051473
20 µg, 100 µg

DCDC2 Overview

Facts about Doublecortin domain-containing protein 2.

DCDC2 3D structure. Source: alphafold

Doublecortin domain-containing protein 2 (DCDC2)

Protein which plays a role in the inhibition of canonical Wnt signaling pathway (PubMed:25557784). May be involved in neuronal migration during development of the cerebral neocortex (By similarity).

Involved in the control of ciliogenesis and ciliary length (PubMed:25601850, PubMed:27319779). .

Gene Information

Human
Gene Name:	DCDC2
Uniprot:	Q9UHG0
Entrez:	51473

Family

Belongs to:

No superfamily

Alternative Names

DCDC2A; doublecortin domain containing 2; KIAA1154Protein RU2S; RU2doublecortin domain-containing protein 2; RU2S

Molecular Weight

Mass (kDA):
52.834 kDA

Genomic Context


Human

Location:	6p22.3
Sequence:	6; NC_000006.12 (24171755..24383292, complement)

Tissue Specificity

Ubiquitously expressed. In brain, highly expressed in the entorhinal cortex, inferior temporal cortex, medial temporal cortex, hypothalamus, amygdala and hippocampus (PubMed:10601354, PubMed:16278297). Expressed in liver by cholangiocytes, the epithelial cells of the bile ducts (at protein level) (PubMed:27319779).

Subcellular Localizations

Cell projection, cilium. Cytoplasm, cytoskeleton, cilium axoneme. Cell projection, kinocilium. Cytoplasm, cytoskeleton. Localizes to the ciliary axoneme and to mitotic spindle fibers in a cell-cycle-dependent manner.

Diseases

Dyslexia
Developmental Reading Disorder
Dysequilibrium Syndrome
Impairment (finding)
Learning Disorders
Attention Deficit Hyperactivity Disorder
Specific Language Impairment
Learning Disabilities
Ectopic Tissue
Language Disorders
Language Development Disorders
Inattention

Nervous System Disorder
Developmental Disabilities
Blind Vision
Epilepsy
Succinate-semialdehyde Dehydrogenase Deficiency
Fracture Of First Cervical Vertebra
Malnutrition

Interacting Proteins

MRFAP1
NIF3L1

Pathways

Brain Development
Cognition
Localization
Rna Interference
Neurogenesis
Short-term Memory
Neuron Migration
Cell Migration

Cell Motility
Prepulse Inhibition
Long-term Memory

PTMs

Acetylation

Research Areas

Signal Transduction
Vision

For details, visit:
bosterbio.com/bosterbio-gene-info-cards/DCDC2

References

PMID: 10601354 by Van den Eynde B.J., et al. A new antigen recognized by cytolytic T lymphocytes on a human kidney tumor results from reverse strand transcription.

PMID: 16278297 by Meng H., et al. DCDC2 is associated with reading disability and modulates neuronal development in the brain.